← Scrub Notes · Reference library

Audited-content ledger

Audit status: preliminary — not commercially certified.

This register inventories the actual learning items and lists potential source references, rights, and clinical-review issues. A topical source match does not prove an item was individually checked against its linked source. Original replacement graphics are marked separately. There has not been a professional per-medication or per-rhythm clinical signoff.

Contents: 17 chapters; 102 knowledge checks; 180 exam questions; 96 flashcards; 24 replaced original diagrams; 300 pharmacology profiles; 22 interaction examples.

Questions and flashcards — item-by-item

All choices are checked for a four-option structure, duplicates, and high-risk wording. Clinical interpretation and provenance still require subject-matter review.

IDChapterPromptExpected answerReading sourcesScreen flags
CHECK-resp-1-01resp-1A chest tube is placed for a pneumothorax. What is the tube intended to remove?Air from the pleural spaceOR-SK OR-ADV OR-RSPNo heuristic flags
CHECK-resp-1-02resp-1Continuous bubbling is observed in a chest drain's WATER-SEAL chamber. What should the nurse consider?An ongoing air leak in the patient or drainage circuitOR-SK OR-ADV OR-RSPNo heuristic flags
CHECK-resp-1-03resp-1A patient with a chest tube suddenly becomes hypotensive and severely dyspneic. What takes priority?Assess ABCs and urgently escalate for possible tension physiologyOR-SK OR-ADV OR-RSPNo heuristic flags
CHECK-resp-1-04resp-1Which setup best supports effective chest drainage?Keep the collection device upright below the insertion siteOR-SK OR-ADV OR-RSPNo heuristic flags
CHECK-resp-1-05resp-1A chest tube has suddenly drained brisk bright-red blood. What is the safest nursing response?Reassess vitals and perfusion and notify the treating team urgentlyOR-SK OR-ADV OR-RSPNo heuristic flags
CHECK-resp-1-06resp-1Why should a bubbling chest tube not be clamped routinely?Trapped pleural air can cause tension pneumothoraxOR-SK OR-ADV OR-RSPNo heuristic flags
CHECK-resp-2-01resp-2An ABG shows pH 7.29, PaCO₂ 56, HCO₃⁻ 25. What is the primary disturbance?Respiratory acidosisOR-HA OR-RSP OR-ADVNo heuristic flags
CHECK-resp-2-02resp-2Which ABG variable best represents the metabolic BASE component?HCO₃⁻OR-HA OR-RSP OR-ADVNo heuristic flags
CHECK-resp-2-03resp-2A patient on supplemental oxygen has a PaO₂ of 145 mmHg. What does this mean?The oxygen tension can exceed 100 mmHg when FiO₂ is increasedOR-HA OR-RSP OR-ADVNo heuristic flags
CHECK-resp-2-04resp-2A patient has HCO₃⁻ 12 mEq/L during metabolic acidosis. Winter's formula predicts which PaCO₂ range?About 24–28 mmHgOR-HA OR-RSP OR-ADVnumerical-clinical-specificity-check
CHECK-resp-2-05resp-2Which statement about a near-normal pH with abnormal PaCO₂ and HCO₃⁻ is safest?It may represent compensation OR a mixed disorder requiring further assessmentOR-HA OR-RSP OR-ADVnon-generic-legacy-wording
CHECK-resp-2-06resp-2Which equation calculates the anion gap WITHOUT potassium?Na⁺ − (Cl⁻ + HCO₃⁻)OR-HA OR-RSP OR-ADVNo heuristic flags
CHECK-resp-3-01resp-3After opioid exposure, a patient becomes somnolent and hypoventilates. Which primary acid–base problem is most likely?Respiratory acidosis from CO₂ retentionOR-HA OR-ADVNo heuristic flags
CHECK-resp-3-02resp-3A patient with sudden tachypnea and perioral tingling has a low PaCO₂. What condition should be considered without assuming anxiety?Respiratory alkalosis associated with causes such as PE or hypoxemiaOR-HA OR-ADVNo heuristic flags
CHECK-resp-3-03resp-3A patient with DKA has pH 7.24, HCO₃⁻ 12, and rapid deep breaths. Why is the respiratory rate elevated?Compensation lowers PaCO₂ to offset metabolic acidosisOR-HA OR-ADVNo heuristic flags
CHECK-resp-3-04resp-3After persistent vomiting and gastric suction, HCO₃⁻ rises to 36. What disorder best matches?Metabolic alkalosis due to acid lossOR-HA OR-ADVNo heuristic flags
CHECK-resp-3-05resp-3An ABG is pH 7.50, PaCO₂ 47, HCO₃⁻ 35. Which interpretation best fits the guide?Metabolic alkalosis with respiratory compensationOR-HA OR-ADVnon-generic-legacy-wording
CHECK-resp-3-06resp-3Which response is most appropriate to severe metabolic acidosis caused by shock?Treat the cause and restore perfusion while monitoring ventilation and electrolytesOR-HA OR-ADVNo heuristic flags
CHECK-resp-4-01resp-4Why can a large pulmonary embolism cause acute right-sided heart strain?It blocks pulmonary vessels, raising right ventricular afterloadPE26 OR-HANo heuristic flags
CHECK-resp-4-02resp-4A recently immobilized patient develops sudden pleuritic pain, dyspnea and tachycardia. What should the nurse do first?Assess stability and promptly escalate suspected PEPE26 OR-HANo heuristic flags
CHECK-resp-4-03resp-4A low-probability patient has an appropriately selected NEGATIVE D-dimer test. How is the result generally used?It can help exclude PE when paired with suitable pretest probabilityPE26 OR-HANo heuristic flags
CHECK-resp-4-04resp-4What imaging is commonly used to confirm PE when appropriate?CT pulmonary angiographyPE26 OR-HANo heuristic flags
CHECK-resp-4-05resp-4A patient with suspected high-risk PE becomes hypotensive and confused. Which priority is most appropriate?Activate urgent response while supporting oxygenation and circulationPE26 OR-HANo heuristic flags
CHECK-resp-4-06resp-4A patient receiving heparin for PE needs monitoring. Which statement is accurate?Use the ordered aPTT or anti-Xa protocol and monitor for bleedingPE26 OR-HAdrug-guidance-check
CHECK-resp-5-01resp-5An ABG shows PaO₂ 54 mmHg on room air with pulmonary edema. What failure pattern is most directly suggested?Type 1 hypoxemic respiratory failureOR-RSP ATS-ARDSNo heuristic flags
CHECK-resp-5-02resp-5A COPD patient has pH 7.26 and PaCO₂ 68 with fatigue. Which dysfunction is central?Inadequate alveolar ventilation causing hypercapniaOR-RSP ATS-ARDSNo heuristic flags
CHECK-resp-5-03resp-5Which change is especially concerning in a struggling respiratory patient?Increasing exhaustion and inability to protect the airwayOR-RSP ATS-ARDSNo heuristic flags
CHECK-resp-5-04resp-5Which oxygen strategy is commonly used initially for COPD patients at risk of CO₂ retention, pending ABGs?Controlled oxygen with an SpO₂ target around 88–92%OR-RSP ATS-ARDSnon-generic-legacy-wording, absolute-claim-check
CHECK-resp-5-05resp-5Pneumonia causes poor oxygen transfer, while opioid overdose causes hypoventilation. Which matching is correct?Pneumonia commonly causes Type 1; opioid overdose commonly causes Type 2OR-RSP ATS-ARDSNo heuristic flags
CHECK-resp-5-06resp-5When choosing respiratory support for acute failure, what besides SpO₂ must be assessed?Work of breathing, mental status, ventilation, and hemodynamicsOR-RSP ATS-ARDSNo heuristic flags
CHECK-resp-6-01resp-6A chest-drain patient develops sudden distress. Which first sequence is appropriate?Assess ABCs, inspect the system, consider tension physiology, and escalateOR-RSP PE26 OR-SKNo heuristic flags
CHECK-resp-6-02resp-6An ABG shows severe acidemia in an unstable ICU patient. Which associated issues need immediate assessment?Ventilation, perfusion, cause, and electrolytesOR-RSP PE26 OR-SKNo heuristic flags
CHECK-resp-6-03resp-6A suspected PE patient becomes hypotensive. What is the priority?Activate emergency response and support breathing/circulationOR-RSP PE26 OR-SKNo heuristic flags
CHECK-resp-6-04resp-6Chest tube output suddenly increases and becomes very bloody. What should be done?Reassess vitals and hemodynamics and report the change promptlyOR-RSP PE26 OR-SKNo heuristic flags
CHECK-resp-6-05resp-6A patient has low PaO₂ despite oxygen equipment in place. Which assessment is most useful initially?Confirm delivery equipment and evaluate lung/ventilation–perfusion problemsOR-RSP PE26 OR-SKNo heuristic flags
CHECK-resp-6-06resp-6What is the safest general priority when several monitor numbers are abnormal?Address the immediately threatening airway, breathing, and perfusion issue firstOR-RSP PE26 OR-SKNo heuristic flags
CHECK-vent-1-01vent-1A patient develops stridor and facial swelling. Which ABCDE element requires immediate attention?Airway patencyOR-ADV OR-SKNo heuristic flags
CHECK-vent-1-02vent-1A restless patient becomes severely fatigued while breathing rapidly. How should this trend be interpreted?Possible respiratory deterioration requiring rapid reassessmentOR-ADV OR-SKNo heuristic flags
CHECK-vent-1-03vent-1SpO₂ is 98%, but the patient is cool and poorly perfused. What is the key distinction?Blood oxygen saturation can look normal despite inadequate tissue perfusionOR-ADV OR-SKNo heuristic flags
CHECK-vent-1-04vent-1What belongs in the Disability step of ABCDE?Neurologic status and blood glucoseOR-ADV OR-SKNo heuristic flags
CHECK-vent-1-05vent-1What best defines a ventilation–perfusion mismatch?Airflow and pulmonary blood flow are poorly matchedOR-ADV OR-SKNo heuristic flags
CHECK-vent-1-06vent-1What is the correct first principle when monitors disagree with the bedside appearance?Assess the patient and verify airway, breathing and perfusionOR-ADV OR-SKNo heuristic flags
CHECK-vent-2-01vent-2Which oxygen device is designed to deliver a controlled FiO₂ using a specified adapter?Venturi maskOR-ADV OR-RSPNo heuristic flags
CHECK-vent-2-02vent-2A non-rebreather is set to an appropriate high flow. Which statement is most accurate?It provides high oxygen concentration but not a guaranteed 100% FiO₂OR-ADV OR-RSPabsolute-claim-check
CHECK-vent-2-03vent-2A patient fails conventional oxygen and becomes more somnolent with worsening work of breathing. What is the priority?Urgent reassessment and escalation of respiratory supportOR-ADV OR-RSPNo heuristic flags
CHECK-vent-2-04vent-2What is the preferred ongoing bedside method to confirm a placed endotracheal tube remains tracheal?Sustained waveform capnography with clinical reassessmentOR-ADV OR-RSPNo heuristic flags
CHECK-vent-2-05vent-2Why must a paralyzed intubated patient still receive appropriate sedation and analgesia?Neuromuscular blockade prevents movement but does not relieve pain or ensure unconsciousnessOR-ADV OR-RSPNo heuristic flags
CHECK-vent-2-06vent-2Which ETT detail should the nurse trend after repositioning?Depth marking at lips/teeth and bilateral chest movementOR-ADV OR-RSPNo heuristic flags
CHECK-vent-3-01vent-3A ventilator's PEEP setting is increased. What is the intended oxygenation benefit?Improved alveolar recruitment at end expirationATS-ARDS OR-ADVNo heuristic flags
CHECK-vent-3-02vent-3A patient becomes hypotensive after a large increase in positive-pressure support. What mechanism may explain this?Higher intrathoracic pressure reduces venous return and cardiac outputATS-ARDS OR-ADVNo heuristic flags
CHECK-vent-3-03vent-3A ventilator displays a new HIGH airway pressure alarm. What problem should be assessed?Kinked tubing, secretions, biting, or reduced complianceATS-ARDS OR-ADVNo heuristic flags
CHECK-vent-3-04vent-3A LOW-pressure/low-volume alarm occurs. What is a likely initial cause to check?Disconnected circuit, leak or cuff problemATS-ARDS OR-ADVNo heuristic flags
CHECK-vent-3-05vent-3Which statement distinguishes Assist-Control (AC) from SIMV?AC supports mandatory breaths triggered by time or patient; SIMV schedules mandatory breaths with spontaneous breaths betweenATS-ARDS OR-ADVNo heuristic flags
CHECK-vent-3-06vent-3For lung-protective ventilation, tidal volume is commonly calculated using which weight?Predicted body weight, often around 4–8 mL/kg depending on contextATS-ARDS OR-ADVnumerical-clinical-specificity-check
CHECK-vent-4-01vent-4During an SBT, a patient develops increasing work of breathing and obvious respiratory fatigue. What does this indicate?SBT intolerance requiring reassessmentAARC24 OR-ADVNo heuristic flags
CHECK-vent-4-02vent-4Which group of findings supports SBT TOLERANCE?Comfortable breathing, stable vitals, acceptable oxygenation, and mentationAARC24 OR-ADVNo heuristic flags
CHECK-vent-4-03vent-4During a trial, respiratory rate rises sharply and tidal volume falls. What is the best interpretation?The patient may be tiring and failing the trialAARC24 OR-ADVNo heuristic flags
CHECK-vent-4-04vent-4A patient maintains SpO₂ 96% during an SBT but is unable to cough or clear secretions. What is the key concern?Adequate oxygenation alone does not establish safe extubation readinessAARC24 OR-ADVNo heuristic flags
CHECK-vent-4-05vent-4Why are spontaneous awakening and breathing trials considered together in liberation planning?Sedation level can obscure respiratory drive and readiness; both require assessmentAARC24 OR-ADVNo heuristic flags
CHECK-vent-4-06vent-4Which development during an SBT calls for closer evaluation rather than automatic extubation?New hemodynamic instability or arrhythmiaAARC24 OR-ADVNo heuristic flags
CHECK-vent-5-01vent-5What is the approximate MAP for a blood pressure of 90/60 mmHg?70 mmHgOR-ADV OR-SKNo heuristic flags
CHECK-vent-5-02vent-5An arterial line waveform becomes damped after the transducer is moved. What should be checked?Leveling/zeroing, air, clot, tubing and waveform qualityOR-ADV OR-SKNo heuristic flags
CHECK-vent-5-03vent-5What event creates the dicrotic notch in an arterial pressure waveform?Aortic valve closureOR-ADV OR-SKNo heuristic flags
CHECK-vent-5-04vent-5Why isn't one CVP value a reliable standalone measure of fluid responsiveness?CVP is influenced by right-heart function and intrathoracic pressure, not simply preload needOR-ADV OR-SKNo heuristic flags
CHECK-vent-5-05vent-5A patient with shock has MAP near 65, but urine output falls and mentation worsens. What should the nurse recognize?Perfusion may still be inadequate despite one acceptable MAPOR-ADV OR-SKNo heuristic flags
CHECK-vent-5-06vent-5Why might a pulmonary artery catheter be used in selected complex shock cases?To measure advanced right-sided and pulmonary pressures and cardiac outputOR-ADV OR-SKNo heuristic flags
CHECK-vent-6-01vent-6Which bundled actions help lower ventilator-associated pneumonia risk?Head elevation when feasible, oral hygiene, aspiration precautions, and liberation readinessOR-SK OR-ADV AHA25No heuristic flags
CHECK-vent-6-02vent-6A critically ill patient's urine output is 0.4 mL/kg/h for six hours. What is the concern?It meets a commonly used urine-output criterion for possible AKIOR-SK OR-ADV AHA25numerical-clinical-specificity-check
CHECK-vent-6-03vent-6An ICU patient becomes disoriented after poor sleep and escalating sedatives. What prevention strategy fits the guide?Review pain, medications, sleep, orientation and mobilityOR-SK OR-ADV AHA25non-generic-legacy-wording
CHECK-vent-6-04vent-6During an arrest, the team leader requests epinephrine. Which communication demonstrates closed-loop practice?The nurse repeats the order and confirms when it is completedOR-SK OR-ADV AHA25No heuristic flags
CHECK-vent-6-05vent-6A patient has SpO₂ 97% but rising lactate, cool skin, and confusion. What is the main concern?Inadequate tissue perfusion or oxygen delivery despite acceptable saturationOR-SK OR-ADV AHA25No heuristic flags
CHECK-vent-6-06vent-6What is an appropriate prevention priority for an immobile critically ill patient?Assess VTE prevention and skin protection while promoting safe mobilityOR-SK OR-ADV AHA25non-generic-legacy-wording
CHECK-ecg-1-01ecg-1On a normal ECG, what electrical event is represented by the P wave?Atrial depolarizationOR-HA AHA25No heuristic flags
CHECK-ecg-1-02ecg-1A six-second strip contains eight QRS complexes. What is the estimated rate?80 beats/minOR-HA AHA25No heuristic flags
CHECK-ecg-1-03ecg-1At paper speed 25 mm/s, one SMALL box represents how much time?0.04 secondsOR-HA AHA25No heuristic flags
CHECK-ecg-1-04ecg-1What PR interval is typically within the adult reference range?0.12–0.20 secondsOR-HA AHA25No heuristic flags
CHECK-ecg-1-05ecg-1A wide, fast QRS rhythm appears while the patient is unstable. What is the safest interpretation strategy?Consider ventricular tachycardia until expertly assessed while checking pulse/perfusionOR-HA AHA25non-generic-legacy-wording
CHECK-ecg-1-06ecg-1The ECG monitor shows organized complexes, but the patient has no pulse. What does this prove?Electrical complexes do not guarantee mechanical cardiac outputOR-HA AHA25absolute-claim-check
CHECK-ecg-2-01ecg-2A rhythm is regular at 125 bpm with a consistent P before each narrow QRS. What is it?Sinus tachycardiaAHA25 OR-HANo heuristic flags
CHECK-ecg-2-02ecg-2A stable patient has a sudden-onset regular narrow tachycardia with P waves obscured. What is an appropriate initial rhythm-specific approach?Vagal maneuvers, then adenosine when indicatedAHA25 OR-HAdrug-guidance-check
CHECK-ecg-2-03ecg-2The rhythm is irregularly irregular with no identifiable consistent P waves. What does this suggest?Atrial fibrillationAHA25 OR-HANo heuristic flags
CHECK-ecg-2-04ecg-2A tracing has organized sawtooth atrial activity. What is the most likely rhythm?Atrial flutterAHA25 OR-HANo heuristic flags
CHECK-ecg-2-05ecg-2An early narrow QRS is preceded by a different-shaped P wave. What is the best identification?Premature atrial contraction (PAC)AHA25 OR-HANo heuristic flags
CHECK-ecg-2-06ecg-2What clinical consideration matters before cardioversion for atrial fibrillation?Onset/duration, anticoagulation and hemodynamic urgencyAHA25 OR-HANo heuristic flags
CHECK-ecg-3-01ecg-3A wide early beat has no related preceding P and is followed by a pause. Which rhythm feature is present?Premature ventricular complex (PVC)AHA25 OR-HANo heuristic flags
CHECK-ecg-3-02ecg-3A patient has monomorphic VT with a pulse but hypotension and altered mental status. Which response is appropriate?Urgent synchronized cardioversionAHA25 OR-HANo heuristic flags
CHECK-ecg-3-03ecg-3A patient has VF on the monitor and no pulse. What takes priority?High-quality CPR and rapid defibrillationAHA25 OR-HANo heuristic flags
CHECK-ecg-3-04ecg-3The monitor shows organized complexes but the patient has no pulse. What is the correct classification and action?PEA: CPR, epinephrine, and reversible-cause assessmentAHA25 OR-HANo heuristic flags
CHECK-ecg-3-05ecg-3Which feature most specifically supports torsades de pointes?Polymorphic VT associated with prolonged QTAHA25 OR-HAdrug-guidance-check
CHECK-ecg-3-06ecg-3When is a shock unsynchronized rather than R-wave synchronized?VF, pulseless VT, or unstable sustained polymorphic VTAHA25 OR-HANo heuristic flags
CHECK-ecg-4-01ecg-4Each P wave leads to a QRS, but PR is consistently 0.26 seconds. What conduction pattern is present?First-degree AV blockAHA25 OR-HANo heuristic flags
CHECK-ecg-4-02ecg-4The PR interval gets progressively longer until a P wave is not followed by a QRS. What is this?Second-degree AV block, Mobitz IAHA25 OR-HANo heuristic flags
CHECK-ecg-4-03ecg-4A rhythm has identical PR intervals on conducted beats, then an on-time P wave fails to conduct. What is it?Second-degree AV block, Mobitz IIAHA25 OR-HANo heuristic flags
CHECK-ecg-4-04ecg-4P waves and QRS complexes march independently at separate regular rates. What does this demonstrate?Third-degree AV block (AV dissociation)AHA25 OR-HANo heuristic flags
CHECK-ecg-4-05ecg-4Why is Mobitz II usually more urgent than first-degree AV block?It can progress abruptly to high-grade or complete block and may need pacingAHA25 OR-HANo heuristic flags
CHECK-ecg-4-06ecg-4A 2:1 AV block shows every second P wave blocked. What interpretation caution applies?It may not be possible to distinguish Mobitz I from II using that strip aloneAHA25 OR-HAabsolute-claim-check
CHECK-ecg-5-01ecg-5Pacing spikes are visible, but some ventricular spikes are NOT followed by QRS complexes. What malfunction is suspected?Failure to captureAHA25 OR-PHNo heuristic flags
CHECK-ecg-5-02ecg-5A pacing device should fire during a prolonged pause, but no spike appears. What problem is suggested?Failure to output (failure to pace)AHA25 OR-PHNo heuristic flags
CHECK-ecg-5-03ecg-5Pacing spikes appear despite well-timed intrinsic beats, sometimes near their QRS or T waves. Which malfunction is suspected?Failure to sense (undersensing)AHA25 OR-PHNo heuristic flags
CHECK-ecg-5-04ecg-5Which change is commonly associated with severe hyperkalemia?Peaked T waves with possible PR prolongation and QRS wideningAHA25 OR-PHNo heuristic flags
CHECK-ecg-5-05ecg-5A patient has prolonged QT and torsades risk in the setting of low magnesium. Which treatment principle belongs in the guide?Magnesium sulfate and correction of contributing electrolytes/causesAHA25 OR-PHnon-generic-legacy-wording, drug-guidance-check
CHECK-ecg-5-06ecg-5IV calcium is ordered for severe hyperkalemia with ECG changes. What is its primary immediate purpose?Stabilize cardiac membranes, not directly lower serum potassiumAHA25 OR-PHdrug-guidance-check
EXAM-1-01vent-4During an SBT, a patient develops increasing work of breathing and obvious respiratory fatigue. What does this indicate?SBT intolerance requiring reassessmentAARC24 OR-ADVNo heuristic flags
EXAM-1-02vent-6How should vascular access infection risk be reduced?Aseptic line care and removing unnecessary devicesOR-SK OR-ADV AHA25No heuristic flags
EXAM-1-03ecg-2For junctional rhythm, which reversible contributor should be evaluated?Digoxin toxicity or myocardial ischemiaAHA25 OR-HANo heuristic flags
EXAM-1-04vent-6What reduces ICU delirium risk in supportive care?Address pain, sleep, orientation, medication burden and mobilityOR-SK OR-ADV AHA25No heuristic flags
EXAM-1-05vent-5What complication must be considered with PA catheter use?Dysrhythmia, infection, thrombosis or PA injuryOR-ADV OR-SKNo heuristic flags
EXAM-1-06resp-1A chest tube is placed for a pneumothorax. What is the tube intended to remove?Air from the pleural spaceOR-SK OR-ADV OR-RSPNo heuristic flags
EXAM-1-07resp-1Which pleural problem requires emergency decompression when tension physiology develops?Trapped pleural air under pressureOR-SK OR-ADV OR-RSPNo heuristic flags
EXAM-1-08resp-4Why can a PE increase right ventricular strain?It obstructs pulmonary arterial flowPE26 OR-HANo heuristic flags
EXAM-1-09resp-5An ABG shows PaO₂ 54 mmHg on room air with pulmonary edema. What failure pattern is most directly suggested?Type 1 hypoxemic respiratory failureOR-RSP ATS-ARDSNo heuristic flags
EXAM-1-10resp-1Which bedside finding after chest tube placement merits urgent escalation?New respiratory distress and crepitusOR-SK OR-ADV OR-RSPNo heuristic flags
EXAM-1-11ecg-4What does 2:1 AV conduction prevent in some cases?Reliable subtyping as Mobitz I versus II from strip aloneAHA25 OR-HANo heuristic flags
EXAM-1-12vent-1What does the C in ABCDE include?Pulse, BP, skin perfusion, mentation and urine outputOR-ADV OR-SKNo heuristic flags
EXAM-1-13vent-2Which oxygen device is designed to deliver a controlled FiO₂ using a specified adapter?Venturi maskOR-ADV OR-RSPNo heuristic flags
EXAM-1-14resp-4Which symptom cluster raises concern for PE?Sudden dyspnea and pleuritic chest painPE26 OR-HANo heuristic flags
EXAM-1-15ecg-1What must be assessed before acting on an ECG finding?Pulse and patient perfusion/stabilityOR-HA AHA25No heuristic flags
EXAM-1-16vent-2A non-rebreather is set to an appropriate high flow. Which statement is most accurate?It provides high oxygen concentration but not a guaranteed 100% FiO₂OR-ADV OR-RSPabsolute-claim-check
EXAM-1-17vent-4Which group of findings supports SBT TOLERANCE?Comfortable breathing, stable vitals, acceptable oxygenation, and mentationAARC24 OR-ADVNo heuristic flags
EXAM-1-18vent-3A ventilator's PEEP setting is increased. What is the intended oxygenation benefit?Improved alveolar recruitment at end expirationATS-ARDS OR-ADVNo heuristic flags
EXAM-1-19vent-1Which sign can be an early indicator of critical respiratory deterioration?Restlessness and tachypneaOR-ADV OR-SKNo heuristic flags
EXAM-1-20ecg-5What ECG finding is associated with hyperkalemia?Peaked T waves and possible QRS wideningAHA25 OR-PHNo heuristic flags
EXAM-1-21resp-5Which finding indicates worsening respiratory failure and urgent escalation?Unable to protect airway or worsening consciousnessOR-RSP ATS-ARDSNo heuristic flags
EXAM-1-22resp-2An ABG shows pH 7.29, PaCO₂ 56, HCO₃⁻ 25. What is the primary disturbance?Respiratory acidosisOR-HA OR-RSP OR-ADVNo heuristic flags
EXAM-1-23ecg-1On a normal ECG, what electrical event is represented by the P wave?Atrial depolarizationOR-HA AHA25No heuristic flags
EXAM-1-24ecg-3What is first priority for VF arrest?Immediate CPR and defibrillationAHA25 OR-HANo heuristic flags
EXAM-1-25resp-2Which ABG variable best represents the metabolic BASE component?HCO₃⁻OR-HA OR-RSP OR-ADVNo heuristic flags
EXAM-1-26ecg-5Pacing spikes are visible, but some ventricular spikes are NOT followed by QRS complexes. What malfunction is suspected?Failure to captureAHA25 OR-PHNo heuristic flags
EXAM-1-27vent-2A patient fails conventional oxygen and becomes more somnolent with worsening work of breathing. What is the priority?Urgent reassessment and escalation of respiratory supportOR-ADV OR-RSPNo heuristic flags
EXAM-1-28resp-4How is a warfarin effect generally monitored?INRPE26 OR-HANo heuristic flags
EXAM-1-29vent-5What can cause a damped arterial pressure waveform?Air bubbles, clot, or line mechanicsOR-ADV OR-SKNo heuristic flags
EXAM-1-30ecg-5How does hypercalcemia often affect QT?Shortens QTAHA25 OR-PHdrug-guidance-check
EXAM-1-31vent-6Which bundled actions help lower ventilator-associated pneumonia risk?Head elevation when feasible, oral hygiene, aspiration precautions, and liberation readinessOR-SK OR-ADV AHA25No heuristic flags
EXAM-1-32ecg-2Which rhythm has sawtooth F waves?Atrial flutterAHA25 OR-HANo heuristic flags
EXAM-1-33resp-1Continuous bubbling is observed in a chest drain's WATER-SEAL chamber. What should the nurse consider?An ongoing air leak in the patient or drainage circuitOR-SK OR-ADV OR-RSPNo heuristic flags
EXAM-1-34ecg-4Which AV block often needs no intervention when stable?First-degree AV blockAHA25 OR-HANo heuristic flags
EXAM-1-35vent-3A patient becomes hypotensive after a large increase in positive-pressure support. What mechanism may explain this?Higher intrathoracic pressure reduces venous return and cardiac outputATS-ARDS OR-ADVNo heuristic flags
EXAM-1-36vent-3A ventilator displays a new HIGH airway pressure alarm. What problem should be assessed?Kinked tubing, secretions, biting, or reduced complianceATS-ARDS OR-ADVNo heuristic flags
EXAM-1-37vent-1In the ABCDE assessment, what does D represent?Disability: neurologic status and glucoseOR-ADV OR-SKNo heuristic flags
EXAM-1-38ecg-1A six-second strip contains eight QRS complexes. What is the estimated rate?80 beats/minOR-HA AHA25No heuristic flags
EXAM-1-39ecg-3What is correct for asystole?Verify rhythm/leads, begin CPR and epinephrine, do not shockAHA25 OR-HANo heuristic flags
EXAM-1-40ecg-2What treatment is needed for a hemodynamically stable normal sinus rhythm?No rhythm-specific treatmentAHA25 OR-HANo heuristic flags
EXAM-1-41ecg-5A pacing device should fire during a prolonged pause, but no spike appears. What problem is suggested?Failure to output (failure to pace)AHA25 OR-PHNo heuristic flags
EXAM-1-42ecg-4What is first-degree AV block?Every P conducts but PR is greater than 0.20 sAHA25 OR-HANo heuristic flags
EXAM-1-43vent-5Which target is commonly used as a starting MAP goal in shock, subject to individualization?About 65 mmHgOR-ADV OR-SKNo heuristic flags
EXAM-1-44vent-1What is a later concerning sign of respiratory deterioration?Exhaustion and decreased consciousnessOR-ADV OR-SKNo heuristic flags
EXAM-1-45resp-6A chest-drain patient develops sudden distress. Which first sequence is appropriate?Assess ABCs, inspect the system, consider tension physiology, and escalateOR-RSP PE26 OR-SKNo heuristic flags
EXAM-1-46resp-3After opioid exposure, a patient becomes somnolent and hypoventilates. Which primary acid–base problem is most likely?Respiratory acidosis from CO₂ retentionOR-HA OR-ADVNo heuristic flags
EXAM-1-47resp-4Which imaging study commonly confirms PE when appropriate?CT pulmonary angiographyPE26 OR-HANo heuristic flags
EXAM-1-48ecg-3What electrolyte issue is linked to torsades?Low magnesium, often low potassiumAHA25 OR-HAdrug-guidance-check
EXAM-1-49vent-4During a trial, respiratory rate rises sharply and tidal volume falls. What is the best interpretation?The patient may be tiring and failing the trialAARC24 OR-ADVNo heuristic flags
EXAM-1-50ecg-3What defines a PVC?Premature wide QRS without a related preceding PAHA25 OR-HANo heuristic flags
EXAM-1-51resp-6A low PaO₂ persists despite indicated oxygen support. What do you assess?Oxygen delivery and pulmonary/VQ causesOR-RSP PE26 OR-SKNo heuristic flags
EXAM-1-52vent-4A patient maintains SpO₂ 96% during an SBT but is unable to cough or clear secretions. What is the key concern?Adequate oxygenation alone does not establish safe extubation readinessAARC24 OR-ADVNo heuristic flags
EXAM-1-53ecg-2Which concern guides decisions about anticoagulation in atrial fibrillation?Stroke riskAHA25 OR-HAnon-generic-legacy-wording
EXAM-1-54resp-3A patient with sudden tachypnea and perioral tingling has a low PaCO₂. What condition should be considered without assuming anxiety?Respiratory alkalosis associated with causes such as PE or hypoxemiaOR-HA OR-ADVNo heuristic flags
EXAM-1-55ecg-1What is the usual SA-node intrinsic rate range?60–100 bpmOR-HA AHA25non-generic-legacy-wording
EXAM-1-56resp-5A COPD patient has pH 7.26 and PaCO₂ 68 with fatigue. Which dysfunction is central?Inadequate alveolar ventilation causing hypercapniaOR-RSP ATS-ARDSNo heuristic flags
EXAM-1-57ecg-4How are atrial and ventricular rhythms related in complete heart block?They beat independentlyAHA25 OR-HANo heuristic flags
EXAM-1-58resp-2What is the expected PaCO₂ for HCO₃⁻ = 12 using Winter’s formula?About 26 mmHg (±2)OR-HA OR-RSP OR-ADVNo heuristic flags
EXAM-1-59resp-6An ABG shows severe acidemia in an unstable ICU patient. Which associated issues need immediate assessment?Ventilation, perfusion, cause, and electrolytesOR-RSP PE26 OR-SKNo heuristic flags
EXAM-1-60resp-3A patient with DKA has pH 7.24, HCO₃⁻ 12, and rapid deep breaths. Why is the respiratory rate elevated?Compensation lowers PaCO₂ to offset metabolic acidosisOR-HA OR-ADVNo heuristic flags
EXAM-2-01vent-4What neurologic finding may make extubation unsafe?Inability to protect the airwayAARC24 OR-ADVNo heuristic flags
EXAM-2-02resp-2A patient on supplemental oxygen has a PaO₂ of 145 mmHg. What does this mean?The oxygen tension can exceed 100 mmHg when FiO₂ is increasedOR-HA OR-RSP OR-ADVNo heuristic flags
EXAM-2-03ecg-3Which intervention is needed for pulseless monomorphic VT?CPR and defibrillationAHA25 OR-HANo heuristic flags
EXAM-2-04resp-2A patient has HCO₃⁻ 12 mEq/L during metabolic acidosis. Winter's formula predicts which PaCO₂ range?About 24–28 mmHgOR-HA OR-RSP OR-ADVnumerical-clinical-specificity-check
EXAM-2-05ecg-1At paper speed 25 mm/s, one SMALL box represents how much time?0.04 secondsOR-HA AHA25No heuristic flags
EXAM-2-06ecg-5Pacing spikes appear despite well-timed intrinsic beats, sometimes near their QRS or T waves. Which malfunction is suspected?Failure to sense (undersensing)AHA25 OR-PHNo heuristic flags
EXAM-2-07vent-3Which variable best indicates the minimum mandatory breaths set by the ventilator?Set respiratory rateATS-ARDS OR-ADVNo heuristic flags
EXAM-2-08vent-2Why might sustained capnography suddenly disappear after intubation?Displacement or airway/circuit failure warrants urgent evaluationOR-ADV OR-RSPNo heuristic flags
EXAM-2-09ecg-2Which treatment principle applies to sinus tachycardia?Treat fever, hypovolemia, pain or other causeAHA25 OR-HANo heuristic flags
EXAM-2-10resp-3After persistent vomiting and gastric suction, HCO₃⁻ rises to 36. What disorder best matches?Metabolic alkalosis due to acid lossOR-HA OR-ADVNo heuristic flags
EXAM-2-11ecg-2How does sinus tachycardia differ from many SVTs?Sinus P waves precede QRS and a cause may be presentAHA25 OR-HANo heuristic flags
EXAM-2-12ecg-2What is the first stable regular narrow SVT intervention to consider?Vagal maneuvers and adenosine when appropriateAHA25 OR-HAdrug-guidance-check
EXAM-2-13vent-3A LOW-pressure/low-volume alarm occurs. What is a likely initial cause to check?Disconnected circuit, leak or cuff problemATS-ARDS OR-ADVNo heuristic flags
EXAM-2-14resp-3An ABG is pH 7.50, PaCO₂ 47, HCO₃⁻ 35. Which interpretation best fits the guide?Metabolic alkalosis with respiratory compensationOR-HA OR-ADVnon-generic-legacy-wording
EXAM-2-15resp-4Which condition is a risk factor for pulmonary embolism?Recent surgery with immobilityPE26 OR-HANo heuristic flags
EXAM-2-16vent-6Which data support assessment of kidney injury?Urine output, creatinine, fluid balance and perfusionOR-SK OR-ADV AHA25No heuristic flags
EXAM-2-17vent-6Which nutrient route is generally preferred when feasible in critical care?Enteral nutritionOR-SK OR-ADV AHA25No heuristic flags
EXAM-2-18ecg-3Which antiarrhythmic may be considered for shock-refractory VF/pulseless VT per algorithm?Amiodarone or lidocaineAHA25 OR-HAdrug-guidance-check
EXAM-2-19vent-5Why evaluate lactate and urine output alongside MAP?They add information about organ perfusionOR-ADV OR-SKNo heuristic flags
EXAM-2-20resp-1A patient with a chest tube suddenly becomes hypotensive and severely dyspneic. What takes priority?Assess ABCs and urgently escalate for possible tension physiologyOR-SK OR-ADV OR-RSPNo heuristic flags
EXAM-2-21resp-6A suspected PE patient becomes hypotensive. What is the priority?Activate emergency response and support breathing/circulationOR-RSP PE26 OR-SKNo heuristic flags
EXAM-2-22resp-6Chest tube output suddenly increases and becomes very bloody. What should be done?Reassess vitals and hemodynamics and report the change promptlyOR-RSP PE26 OR-SKNo heuristic flags
EXAM-2-23ecg-1What does the QRS complex represent?Ventricular depolarizationOR-HA AHA25No heuristic flags
EXAM-2-24vent-2What is the preferred ongoing bedside method to confirm a placed endotracheal tube remains tracheal?Sustained waveform capnography with clinical reassessmentOR-ADV OR-RSPNo heuristic flags
EXAM-2-25vent-4Can an SBT be performed with some pressure support?Yes, standardized approaches can use support or notAARC24 OR-ADVnon-generic-legacy-wording
EXAM-2-26ecg-5Which reversible arrest cause belongs to the Hs and Ts?Tension pneumothoraxAHA25 OR-PHNo heuristic flags
EXAM-2-27resp-3What is the key initial treatment principle for metabolic acidosis?Identify and address its causeOR-HA OR-ADVNo heuristic flags
EXAM-2-28resp-2Which statement about a near-normal pH with abnormal PaCO₂ and HCO₃⁻ is safest?It may represent compensation OR a mixed disorder requiring further assessmentOR-HA OR-RSP OR-ADVnon-generic-legacy-wording
EXAM-2-29ecg-5Which change is commonly associated with severe hyperkalemia?Peaked T waves with possible PR prolongation and QRS wideningAHA25 OR-PHNo heuristic flags
EXAM-2-30resp-5Which factor may cause hypercapnic respiratory failure?Opioid-associated hypoventilationOR-RSP ATS-ARDSNo heuristic flags
EXAM-2-31resp-5Which change distinguishes hypercapnic from hypoxemic failure?High PaCO₂ versus primarily low PaO₂OR-RSP ATS-ARDSNo heuristic flags
EXAM-2-32resp-2Which equation calculates the anion gap WITHOUT potassium?Na⁺ − (Cl⁻ + HCO₃⁻)OR-HA OR-RSP OR-ADVNo heuristic flags
EXAM-2-33vent-5What must be checked with an arterial-line transducer?Leveling, zeroing, and waveform qualityOR-ADV OR-SKNo heuristic flags
EXAM-2-34vent-5Which parameter does CVP approximate?Right atrial pressureOR-ADV OR-SKNo heuristic flags
EXAM-2-35vent-1What is the distinction between oxygenation and perfusion?Oxygenation loads blood with O₂; perfusion delivers it to tissueOR-ADV OR-SKabsolute-claim-check
EXAM-2-36ecg-4What defines third-degree block?Independent P and QRS rhythms without fixed PRAHA25 OR-HANo heuristic flags
EXAM-2-37resp-6A patient develops severe respiratory distress with a chest drain. What first?Assess ABCs and check drain/system while escalatingOR-RSP PE26 OR-SKNo heuristic flags
EXAM-2-38resp-4What can a positive D-dimer alone establish?It does not diagnose PEPE26 OR-HANo heuristic flags
EXAM-2-39vent-2Which statement about neuromuscular blockade is correct?Paralysis never replaces sedationOR-ADV OR-RSPabsolute-claim-check
EXAM-2-40ecg-5A patient has prolonged QT and torsades risk in the setting of low magnesium. Which treatment principle belongs in the guide?Magnesium sulfate and correction of contributing electrolytes/causesAHA25 OR-PHnon-generic-legacy-wording, drug-guidance-check
EXAM-2-41resp-5How should respiratory failure treatment be selected?Support oxygenation or ventilation according to the mechanismOR-RSP ATS-ARDSNo heuristic flags
EXAM-2-42ecg-1At 25 mm/s, what does one small ECG square represent?0.04 secondsOR-HA AHA25No heuristic flags
EXAM-2-43resp-5In some COPD patients at risk of CO₂ retention, what usual initial SpO₂ target is described?88–92% pending ABG assessmentOR-RSP ATS-ARDSNo heuristic flags
EXAM-2-44resp-4Which treatment is standard for most confirmed PE if bleeding risk allows?AnticoagulationPE26 OR-HANo heuristic flags
EXAM-2-45vent-3Which problem may cause a high-pressure ventilator alarm?Kinked tube or thick secretionsATS-ARDS OR-ADVNo heuristic flags
EXAM-2-46resp-1Which setup best supports effective chest drainage?Keep the collection device upright below the insertion siteOR-SK OR-ADV OR-RSPNo heuristic flags
EXAM-2-47vent-1Why might normal SpO₂ coexist with shock?Cardiac output and tissue delivery can still be inadequateOR-ADV OR-SKNo heuristic flags
EXAM-2-48ecg-4What should be checked first when block is associated with symptoms?Perfusion and hemodynamic compromiseAHA25 OR-HANo heuristic flags
EXAM-2-49ecg-4Why might atropine be ineffective in complete heart block?Block can be infranodal, requiring pacingAHA25 OR-HAdrug-guidance-check
EXAM-2-50ecg-3Which condition calls for unsynchronized defibrillation rather than synchronized cardioversion?Unstable sustained polymorphic VTAHA25 OR-HANo heuristic flags
EXAM-2-51vent-4Why are spontaneous awakening and breathing trials considered together in liberation planning?Sedation level can obscure respiratory drive and readiness; both require assessmentAARC24 OR-ADVNo heuristic flags
EXAM-2-52ecg-4When Mobitz II is suspected, what should be prepared?Urgent pacing readiness and evaluationAHA25 OR-HANo heuristic flags
EXAM-2-53ecg-3What treatment is used for unstable monomorphic VT with a pulse?Synchronized cardioversionAHA25 OR-HANo heuristic flags
EXAM-2-54ecg-2What defines atrial fibrillation on ECG?Irregularly irregular R–R and no consistent PAHA25 OR-HANo heuristic flags
EXAM-2-55ecg-1What PR interval is typically within the adult reference range?0.12–0.20 secondsOR-HA AHA25No heuristic flags
EXAM-2-56vent-1What is hypoxemia?Low oxygen in arterial bloodOR-ADV OR-SKNo heuristic flags
EXAM-2-57vent-5What can a pulmonary artery catheter measure in selected cases?PA pressures, wedge pressure and cardiac outputOR-ADV OR-SKNo heuristic flags
EXAM-2-58vent-2What should be documented about endotracheal tube position?Mark at lips/teeth and tube inner diameterOR-ADV OR-RSPNo heuristic flags
EXAM-2-59vent-6Which actions reduce ventilator-associated pneumonia risk?Head elevation when feasible and oral hygieneOR-SK OR-ADV AHA25No heuristic flags
EXAM-2-60resp-1A chest tube has suddenly drained brisk bright-red blood. What is the safest nursing response?Reassess vitals and perfusion and notify the treating team urgentlyOR-SK OR-ADV OR-RSPNo heuristic flags
EXAM-3-01vent-1What does E in ABCDE prompt?Inspect for bleeding, injuries, fever, and skin abnormalitiesOR-ADV OR-SKNo heuristic flags
EXAM-3-02vent-6A critically ill patient's urine output is 0.4 mL/kg/h for six hours. What is the concern?It meets a commonly used urine-output criterion for possible AKIOR-SK OR-ADV AHA25numerical-clinical-specificity-check
EXAM-3-03vent-4Which finding favors SBT tolerance?Stable heart rate, blood pressure, and comfortable effortAARC24 OR-ADVNo heuristic flags
EXAM-3-04resp-3What should be assessed during treatment of metabolic alkalosis?Chloride, volume status, and potassiumOR-HA OR-ADVNo heuristic flags
EXAM-3-05ecg-1What does the T wave represent?Ventricular repolarizationOR-HA AHA25No heuristic flags
EXAM-3-06vent-3How does assist-control differ from SIMV?AC supports triggered mandatory breaths; SIMV allows spontaneous breaths between scheduled onesATS-ARDS OR-ADVNo heuristic flags
EXAM-3-07ecg-1What does the P wave represent?Atrial depolarizationOR-HA AHA25No heuristic flags
EXAM-3-08ecg-4What is a nonconducted P wave?Atrial depolarization with no following QRSAHA25 OR-HANo heuristic flags
EXAM-3-09vent-5Approximate MAP for BP 90/60 mmHg using (SBP + 2DBP)/3?70 mmHgOR-ADV OR-SKNo heuristic flags
EXAM-3-10vent-2Why must a paralyzed intubated patient still receive appropriate sedation and analgesia?Neuromuscular blockade prevents movement but does not relieve pain or ensure unconsciousnessOR-ADV OR-RSPNo heuristic flags
EXAM-3-11resp-4What is the initial nursing priority for hemodynamically unstable suspected PE?Activate emergency response and support oxygenation/circulationPE26 OR-HANo heuristic flags
EXAM-3-12resp-4What lab approach may monitor a heparin infusion depending on protocol?aPTT or anti-XaPE26 OR-HAdrug-guidance-check
EXAM-3-13vent-1What is V/Q mismatch?Pulmonary airflow and blood flow are poorly matchedOR-ADV OR-SKNo heuristic flags
EXAM-3-14ecg-3Why does R-on-T PVC merit concern?It may provoke a malignant ventricular arrhythmiaAHA25 OR-HANo heuristic flags
EXAM-3-15resp-3Which condition commonly causes metabolic acidosis?Diabetic ketoacidosisOR-HA OR-ADVNo heuristic flags
EXAM-3-16vent-6An ICU patient becomes disoriented after poor sleep and escalating sedatives. What prevention strategy fits the guide?Review pain, medications, sleep, orientation and mobilityOR-SK OR-ADV AHA25non-generic-legacy-wording
EXAM-3-17vent-6During an arrest, the team leader requests epinephrine. Which communication demonstrates closed-loop practice?The nurse repeats the order and confirms when it is completedOR-SK OR-ADV AHA25No heuristic flags
EXAM-3-18vent-5Why is a CVP reading insufficient by itself to select IV fluids?It does not reliably predict fluid responsivenessOR-ADV OR-SKNo heuristic flags
EXAM-3-19ecg-2What characterizes a PAC?Early abnormal P wave with usually narrow QRSAHA25 OR-HANo heuristic flags
EXAM-3-20vent-4Which development during an SBT calls for closer evaluation rather than automatic extubation?New hemodynamic instability or arrhythmiaAARC24 OR-ADVNo heuristic flags
EXAM-3-21ecg-4What defines Mobitz I?PR grows longer until a P does not conductAHA25 OR-HANo heuristic flags
EXAM-3-22vent-2What does the guide emphasize about a non-rebreather?High oxygen concentration, not reliably 100%OR-ADV OR-RSPnon-generic-legacy-wording, absolute-claim-check
EXAM-3-23ecg-2What is the unstable regular SVT treatment described?Synchronized cardioversionAHA25 OR-HANo heuristic flags
EXAM-3-24resp-3In respiratory acidosis, which primary change is expected?Elevated PaCO₂OR-HA OR-ADVNo heuristic flags
EXAM-3-25vent-1What should take priority over routine abnormalities in critical care?Immediate ABC threatsOR-ADV OR-SKNo heuristic flags
EXAM-3-26ecg-1A wide, fast QRS rhythm appears while the patient is unstable. What is the safest interpretation strategy?Consider ventricular tachycardia until expertly assessed while checking pulse/perfusionOR-HA AHA25non-generic-legacy-wording
EXAM-3-27ecg-5IV calcium is ordered for severe hyperkalemia with ECG changes. What is its primary immediate purpose?Stabilize cardiac membranes, not directly lower serum potassiumAHA25 OR-PHdrug-guidance-check
EXAM-3-28resp-1Why should a bubbling chest tube not be clamped routinely?Trapped pleural air can cause tension pneumothoraxOR-SK OR-ADV OR-RSPNo heuristic flags
EXAM-3-29resp-6A critical ABG shows severe acidemia. What should you prioritize?Ventilation, perfusion, cause, electrolytes and escalationOR-RSP PE26 OR-SKNo heuristic flags
EXAM-3-30vent-2Which ETT detail should the nurse trend after repositioning?Depth marking at lips/teeth and bilateral chest movementOR-ADV OR-RSPNo heuristic flags
EXAM-3-31resp-5What early sign may precede severe respiratory fatigue?Restlessness and tachypneaOR-RSP ATS-ARDSNo heuristic flags
EXAM-3-32resp-1Why must a chest drainage unit stay below insertion level?To reduce backflow and keep drainage functionalOR-SK OR-ADV OR-RSPNo heuristic flags
EXAM-3-33ecg-5A prolonged QT is found in a patient with low calcium. Which association fits the guide?Hypocalcemia can prolong QTAHA25 OR-PHnon-generic-legacy-wording, drug-guidance-check
EXAM-3-34vent-3Which statement distinguishes Assist-Control (AC) from SIMV?AC supports mandatory breaths triggered by time or patient; SIMV schedules mandatory breaths with spontaneous breaths betweenATS-ARDS OR-ADVNo heuristic flags
EXAM-3-35ecg-3What does torsades de pointes imply?Polymorphic VT associated with prolonged QTAHA25 OR-HANo heuristic flags
EXAM-3-36ecg-2What might an inverted retrograde P near a narrow QRS suggest?Junctional rhythmAHA25 OR-HANo heuristic flags
EXAM-3-37vent-5What does the dicrotic notch on arterial waveform relate to?Aortic valve closureOR-ADV OR-SKNo heuristic flags
EXAM-3-38resp-5Which change is especially concerning in a struggling respiratory patient?Increasing exhaustion and inability to protect the airwayOR-RSP ATS-ARDSNo heuristic flags
EXAM-3-39ecg-5What does IV calcium do in severe hyperkalemia when indicated?Stabilizes cardiac membranes without lowering serum potassiumAHA25 OR-PHdrug-guidance-check
EXAM-3-40vent-6A patient has SpO₂ 97% but rising lactate, cool skin, and confusion. What is the main concern?Inadequate tissue perfusion or oxygen delivery despite acceptable saturationOR-SK OR-ADV AHA25No heuristic flags
EXAM-3-41ecg-4Why is Mobitz II concerning?Can progress to complete block and need pacingAHA25 OR-HANo heuristic flags
EXAM-3-42resp-2In chronic respiratory acidosis, which renal response helps compensate over time?Retention of bicarbonate (HCO₃⁻)OR-HA OR-RSP OR-ADVNo heuristic flags
EXAM-3-43ecg-5Which drug is typically used for selected regular AV-node-dependent SVT instead of symptomatic bradycardia?AdenosineAHA25 OR-PHdrug-guidance-check
EXAM-3-44ecg-2How do you recognize normal sinus rhythm?P before each narrow QRS, regular 60–100 bpmAHA25 OR-HANo heuristic flags
EXAM-3-45vent-4Which change suggests failure of an SBT?Increasing respiratory fatigue and severe tachypneaAARC24 OR-ADVNo heuristic flags
EXAM-3-46ecg-1The ECG monitor shows organized complexes, but the patient has no pulse. What does this prove?Electrical complexes do not guarantee mechanical cardiac outputOR-HA AHA25absolute-claim-check
EXAM-3-47ecg-3What characterizes ventricular fibrillation?Chaotic activity without organized QRSAHA25 OR-HANo heuristic flags
EXAM-3-48resp-4What can a normal oxygen saturation tell you about PE?It does not exclude PEPE26 OR-HANo heuristic flags
EXAM-3-49resp-3Which response is most appropriate to severe metabolic acidosis caused by shock?Treat the cause and restore perfusion while monitoring ventilation and electrolytesOR-HA OR-ADVNo heuristic flags
EXAM-3-50ecg-4What defines Mobitz II?Fixed PR on conducted beats with sudden dropped QRSAHA25 OR-HANo heuristic flags
EXAM-3-51resp-2Which oxygenation measurement is obtained noninvasively by a pulse oximeter?SpO₂OR-HA OR-RSP OR-ADVNo heuristic flags
EXAM-3-52ecg-3What is PEA?Organized electrical activity without a palpable pulseAHA25 OR-HAabsolute-claim-check
EXAM-3-53resp-6Suspected PE causes hypotension and altered mentation. What now?Rapid response and circulatory/respiratory supportOR-RSP PE26 OR-SKNo heuristic flags
EXAM-3-54resp-5Which oxygen strategy is commonly used initially for COPD patients at risk of CO₂ retention, pending ABGs?Controlled oxygen with an SpO₂ target around 88–92%OR-RSP ATS-ARDSnon-generic-legacy-wording, absolute-claim-check
EXAM-3-55vent-3Why can increasing PEEP lower blood pressure?Increased intrathoracic pressure reduces venous returnATS-ARDS OR-ADVNo heuristic flags
EXAM-3-56resp-1Which practice is discouraged for routine chest-tube care?Aggressively stripping the tubingOR-SK OR-ADV OR-RSPNo heuristic flags
EXAM-3-57resp-6A patient has low PaO₂ despite oxygen equipment in place. Which assessment is most useful initially?Confirm delivery equipment and evaluate lung/ventilation–perfusion problemsOR-RSP PE26 OR-SKNo heuristic flags
EXAM-3-58resp-2An ABG shows alkalemia and an elevated HCO₃⁻. Which primary process should be evaluated first?Metabolic alkalosisOR-HA OR-RSP OR-ADVNo heuristic flags
EXAM-3-59resp-6What is the safest general priority when several monitor numbers are abnormal?Address the immediately threatening airway, breathing, and perfusion issue firstOR-RSP PE26 OR-SKNo heuristic flags
EXAM-3-60vent-3What is a major concern with high airway pressures or excessive tidal volumes?Ventilator-associated lung injuryATS-ARDS OR-ADVNo heuristic flags
FLASH-f0resp-1What accumulates in the pleural space during a pneumothorax?Air.OR-SK OR-ADV OR-RSPNo heuristic flags
FLASH-f1resp-1Why is tension pneumothorax life-threatening?Trapped pressurized air can cause obstructive shock.OR-SK OR-ADV OR-RSPNo heuristic flags
FLASH-f2resp-1What accumulates in a hemothorax?Blood in the pleural space.OR-SK OR-ADV OR-RSPNo heuristic flags
FLASH-f3resp-1What is a pleural effusion?Excess fluid in the pleural space.OR-SK OR-ADV OR-RSPNo heuristic flags
FLASH-f4resp-1What is an empyema?Infected pleural fluid or pus.OR-SK OR-ADV OR-RSPNo heuristic flags
FLASH-f5resp-1What is a chylothorax?Chyle (lymphatic fluid) in the pleural space.OR-SK OR-ADV OR-RSPNo heuristic flags
FLASH-f6resp-2What is the normal adult arterial pH range?7.35–7.45.OR-HA OR-RSP OR-ADVNo heuristic flags
FLASH-f7resp-2What is the usual adult PaCO₂ range?35–45 mmHg.OR-HA OR-RSP OR-ADVNo heuristic flags
FLASH-f8resp-2What is the usual adult HCO₃⁻ range?22–26 mEq/L (lab-dependent).OR-HA OR-RSP OR-ADVnumerical-clinical-specificity-check
FLASH-f9resp-2What is a typical PaO₂ on room air in a healthy adult?About 80–100 mmHg; varies with age.OR-HA OR-RSP OR-ADVNo heuristic flags
FLASH-f10resp-2What is typical healthy-adult arterial O₂ saturation (SaO₂)?About 95–100%.OR-HA OR-RSP OR-ADVabsolute-claim-check
FLASH-f11resp-2What does SpO₂ measure?Pulse-oximeter estimate of oxygen saturation.OR-HA OR-RSP OR-ADVNo heuristic flags
FLASH-f12resp-3Interpret pH 7.28 / PaCO₂ 55 / HCO₃⁻ 25.Acute/uncompensated respiratory acidosis.OR-HA OR-ADVNo heuristic flags
FLASH-f13resp-3Interpret pH 7.49 / PaCO₂ 29 / HCO₃⁻ 23.Respiratory alkalosis.OR-HA OR-ADVNo heuristic flags
FLASH-f14resp-3Interpret pH 7.25 / PaCO₂ 27 / HCO₃⁻ 12.Metabolic acidosis with expected respiratory compensation.OR-HA OR-ADVNo heuristic flags
FLASH-f15resp-3Interpret pH 7.50 / PaCO₂ 47 / HCO₃⁻ 35.Metabolic alkalosis with respiratory compensation.OR-HA OR-ADVNo heuristic flags
FLASH-f16resp-3Interpret pH 7.36 / PaCO₂ 60 / HCO₃⁻ 33.Compensated chronic respiratory acidosis pattern.OR-HA OR-ADVNo heuristic flags
FLASH-f17resp-3What breathing pattern may occur in severe metabolic acidosis?Deep, rapid Kussmaul respirations.OR-HA OR-ADVNo heuristic flags
FLASH-f18resp-4Why can pulmonary embolism strain the right ventricle?Blocked pulmonary blood flow raises RV afterload.PE26 OR-HANo heuristic flags
FLASH-f19resp-4What symptoms should raise concern for pulmonary embolism?Sudden dyspnea, pleuritic chest pain, and tachycardia.PE26 OR-HANo heuristic flags
FLASH-f20resp-4What recent history increases risk for pulmonary embolism?Surgery or prolonged immobility.PE26 OR-HANo heuristic flags
FLASH-f21resp-4Does a positive D-dimer confirm pulmonary embolism?No. It is nonspecific.PE26 OR-HANo heuristic flags
FLASH-f22resp-4What imaging study commonly confirms suspected PE?CT pulmonary angiography (CTPA).PE26 OR-HANo heuristic flags
FLASH-f23resp-4Can normal SpO₂ rule out pulmonary embolism?No.PE26 OR-HANo heuristic flags
FLASH-f24resp-5What physiological problem defines type 1 respiratory failure?Impaired oxygen transfer (hypoxemia).OR-RSP ATS-ARDSNo heuristic flags
FLASH-f25resp-5Name common causes of type 1 respiratory failure.Pneumonia, pulmonary edema, ARDS, or PE.OR-RSP ATS-ARDSNo heuristic flags
FLASH-f26resp-5What ABG finding strongly suggests type 1 respiratory failure?Low PaO₂, often <60 mmHg on room air.OR-RSP ATS-ARDSNo heuristic flags
FLASH-f27resp-5What are first priorities in type 1 respiratory failure?Support oxygenation and treat the cause.OR-RSP ATS-ARDSNo heuristic flags
FLASH-f28resp-5How do type 1 and type 2 respiratory failure differ?Type 1: low PaO₂. Type 2: elevated PaCO₂.OR-RSP ATS-ARDSNo heuristic flags
FLASH-f29resp-5What is the main mechanism of type 2 respiratory failure?Inadequate alveolar ventilation with CO₂ retention.OR-RSP ATS-ARDSNo heuristic flags
FLASH-f30vent-1How do oxygenation and perfusion differ?Oxygenation loads O₂ into blood; perfusion delivers blood to tissue.OR-ADV OR-SKabsolute-claim-check
FLASH-f31vent-1What early signs suggest respiratory deterioration?Restlessness, tachypnea, or increased breathing effort.OR-ADV OR-SKNo heuristic flags
FLASH-f32vent-1What does V/Q mismatch mean?Airflow and blood flow are poorly matched in the lungs.OR-ADV OR-SKNo heuristic flags
FLASH-f33vent-1What is checked under C (circulation) in ABCDE?Pulse, BP, skin perfusion, mentation, and urine output.OR-ADV OR-SKNo heuristic flags
FLASH-f34vent-1What is the difference between hypoxemia and hypoxia?Hypoxemia: low arterial O₂; hypoxia: inadequate tissue O₂.OR-ADV OR-SKNo heuristic flags
FLASH-f35vent-1What does E (exposure) assess in ABCDE?Bleeding, injury, temperature, and skin abnormalities.OR-ADV OR-SKNo heuristic flags
FLASH-f36vent-2What percentage of inspired oxygen is in room air?21%.OR-ADV OR-RSPNo heuristic flags
FLASH-f37vent-2Which oxygen device delivers a controlled FiO₂?Venturi mask.OR-ADV OR-RSPNo heuristic flags
FLASH-f38vent-2What oxygen range can a non-rebreather provide?High FiO₂, often roughly 60–90%; not reliably 100%.OR-ADV OR-RSPabsolute-claim-check
FLASH-f39vent-2Does neuromuscular paralysis replace sedation?No. Paralysis never replaces sedation.OR-ADV OR-RSPabsolute-claim-check
FLASH-f40vent-2What ETT position details should nurses document?Tube size and depth marking at lips or teeth.OR-ADV OR-RSPNo heuristic flags
FLASH-f41vent-2Why is right-mainstem intubation dangerous?It can preferentially ventilate one lung.OR-ADV OR-RSPNo heuristic flags
FLASH-f42vent-3What does FiO₂ mean on a ventilator?Fraction of inspired oxygen.ATS-ARDS OR-ADVNo heuristic flags
FLASH-f43vent-3What does the ventilator's set rate represent?Minimum mandatory breaths per minute.ATS-ARDS OR-ADVNo heuristic flags
FLASH-f44vent-3What does total respiratory rate include?Mandatory plus patient-triggered/spontaneous breaths.ATS-ARDS OR-ADVNo heuristic flags
FLASH-f45vent-3What is pressure support on a ventilator?Inspiratory assistance for spontaneous breaths.ATS-ARDS OR-ADVNo heuristic flags
FLASH-f46vent-3Why monitor plateau pressure?It helps assess lung-distending pressure.ATS-ARDS OR-ADVNo heuristic flags
FLASH-f47vent-3What does PEEP do for oxygenation?Helps keep alveoli recruited at end expiration.ATS-ARDS OR-ADVNo heuristic flags
FLASH-f48vent-4What breathing signs suggest SBT intolerance?Severe tachypnea, very low tidal volume, or rising effort.AARC24 OR-ADVNo heuristic flags
FLASH-f49vent-4What cardiac signs suggest SBT intolerance?Hemodynamic instability or new arrhythmias.AARC24 OR-ADVNo heuristic flags
FLASH-f50vent-4What mental-status signs threaten safe ventilator liberation?Agitation or inability to protect the airway.AARC24 OR-ADVNo heuristic flags
FLASH-f51vent-4What does a spontaneous breathing trial assess?Ability to breathe with reduced ventilator support.AARC24 OR-ADVNo heuristic flags
FLASH-f52vent-4What should the nurse do if an SBT causes marked fatigue?Stop/reassess the trial and alert the care team.AARC24 OR-ADVNo heuristic flags
FLASH-f53vent-4Beyond SpO₂, what must be assessed before extubation?Airway protection, cough, mentation and secretion control.AARC24 OR-ADVNo heuristic flags
FLASH-f54vent-5Can one CVP reading predict fluid responsiveness?No.OR-ADV OR-SKNo heuristic flags
FLASH-f55vent-5What mechanical event produces the arterial dicrotic notch?Aortic valve closure.OR-ADV OR-SKNo heuristic flags
FLASH-f56vent-5What setup checks matter for arterial-line BP accuracy?Transducer leveling, zeroing, and waveform quality.OR-ADV OR-SKNo heuristic flags
FLASH-f57vent-5What can a pulmonary artery catheter measure?PA pressures, wedge pressure, and cardiac output.OR-ADV OR-SKNo heuristic flags
FLASH-f58vent-5What MAP is a common initial target during shock care?Approximately 65 mmHg, individualized.OR-ADV OR-SKNo heuristic flags
FLASH-f59vent-5What can dampen an arterial-line waveform?Air bubbles, clot, or tubing/line problems.OR-ADV OR-SKNo heuristic flags
FLASH-f60vent-6What routine care helps prevent pressure injury in ICU patients?Repositioning, device checks, and pressure relief.OR-SK OR-ADV AHA25No heuristic flags
FLASH-f61vent-6Which trends help assess evolving acute kidney injury?Urine output, creatinine, fluid balance, and perfusion.OR-SK OR-ADV AHA25No heuristic flags
FLASH-f62vent-6What basic measures lower VAP risk?Head elevation when feasible and oral hygiene.OR-SK OR-ADV AHA25No heuristic flags
FLASH-f63vent-6What sustained urine output can meet an AKI criterion?<0.5 mL/kg/hr for at least 6 hours.OR-SK OR-ADV AHA25numerical-clinical-specificity-check
FLASH-f64vent-6How can ICU nurses help prevent VTE?Early mobility and indicated mechanical/drug prophylaxis.OR-SK OR-ADV AHA25No heuristic flags
FLASH-f65vent-6What helps prevent ICU delirium?Manage pain, sleep, orientation, medications, and mobility.OR-SK OR-ADV AHA25No heuristic flags
FLASH-f66ecg-1How should sinus P waves typically look in lead II?Upright, with one P before each QRS.OR-HA AHA25No heuristic flags
FLASH-f67ecg-1What is the normal adult PR interval?0.12–0.20 seconds.OR-HA AHA25No heuristic flags
FLASH-f68ecg-1How wide is a normal QRS complex?<0.12 seconds.OR-HA AHA25No heuristic flags
FLASH-f69ecg-1What are the approximate intrinsic pacemaker rates?SA 60–100; junction 40–60; ventricular escape 20–40 bpm.OR-HA AHA25No heuristic flags
FLASH-f70ecg-1What electrical event creates the P wave?Atrial depolarization.OR-HA AHA25No heuristic flags
FLASH-f71ecg-1What electrical event creates the QRS complex?Ventricular depolarization.OR-HA AHA25No heuristic flags
FLASH-f72ecg-2How do you recognize normal sinus rhythm?Regular 60–100; P before every narrow QRS.AHA25 OR-HANo heuristic flags
FLASH-f73ecg-2Does stable normal sinus rhythm need a rhythm treatment?No rhythm-specific treatment.AHA25 OR-HANo heuristic flags
FLASH-f74ecg-2What tracing clue helps distinguish sinus tachycardia from SVT?Distinct sinus P waves before QRS complexes.AHA25 OR-HANo heuristic flags
FLASH-f75ecg-2What is the priority in sinus tachycardia management?Treat the underlying cause.AHA25 OR-HANo heuristic flags
FLASH-f76ecg-2What identifies a premature atrial contraction (PAC)?An early, often different-looking P with a usually narrow QRS.AHA25 OR-HANo heuristic flags
FLASH-f77ecg-2What's a typical first approach to stable regular narrow SVT?Vagal maneuver; adenosine when appropriate.AHA25 OR-HAdrug-guidance-check
FLASH-f78ecg-3What ECG feature identifies a PVC?An early wide QRS without a related preceding P.AHA25 OR-HANo heuristic flags
FLASH-f79ecg-3What is the priority for pulseless monomorphic VT?CPR and defibrillation.AHA25 OR-HANo heuristic flags
FLASH-f80ecg-3What treatment is indicated for unstable VT with a pulse?Synchronized cardioversion for monomorphic VT.AHA25 OR-HANo heuristic flags
FLASH-f81ecg-3What is torsades de pointes?Polymorphic VT associated with prolonged QT.AHA25 OR-HANo heuristic flags
FLASH-f82ecg-3Which electrolyte deficits increase torsades risk?Low magnesium and often low potassium.AHA25 OR-HAdrug-guidance-check
FLASH-f83ecg-3What does ventricular fibrillation look like?Chaotic activity with no organized QRS complexes.AHA25 OR-HANo heuristic flags
FLASH-f84ecg-4What is the ECG criterion for first-degree AV block?PR >0.20 seconds; every P still conducts.AHA25 OR-HANo heuristic flags
FLASH-f85ecg-4How do you recognize Mobitz I (Wenckebach)?PR progressively lengthens, then a QRS drops.AHA25 OR-HANo heuristic flags
FLASH-f86ecg-4How do you recognize Mobitz II?Fixed PR on conducted beats with sudden dropped QRS.AHA25 OR-HANo heuristic flags
FLASH-f87ecg-4Why should nurses prepare for pacing in Mobitz II?It may progress abruptly to complete AV block.AHA25 OR-HANo heuristic flags
FLASH-f88ecg-4What defines third-degree AV block?Atrial P waves and QRS complexes occur independently.AHA25 OR-HANo heuristic flags
FLASH-f89ecg-4Why may atropine fail in complete heart block?The block may be infranodal; pacing may be needed.AHA25 OR-HAdrug-guidance-check
FLASH-f90ecg-5How does low calcium affect the ECG's QT interval?Prolongs the QT interval.AHA25 OR-PHdrug-guidance-check
FLASH-f91ecg-5How does high calcium affect the QT interval?Shortens the QT interval.AHA25 OR-PHdrug-guidance-check
FLASH-f92ecg-5How does low magnesium affect ventricular rhythm risk?Prolonged QT and increased torsades risk.AHA25 OR-PHdrug-guidance-check
FLASH-f93ecg-5How can excess magnesium affect cardiac conduction?Bradycardia and AV-conduction depression.AHA25 OR-PHdrug-guidance-check
FLASH-f94ecg-5When is adenosine commonly considered?Selected stable regular AV-node-dependent SVT.AHA25 OR-PHdrug-guidance-check
FLASH-f95ecg-5When may atropine be used in an adult with a pulse?Symptomatic bradycardia with poor perfusion.AHA25 OR-PHdrug-guidance-check

Original replacement illustrations

All 24 formerly embedded figures were replaced with independently drawn SVG schematics, including 16 ECG examples. They are for concepts, not clinical diagnosis. The live ECG simulator was retained separately.

ChapterGraphicFileNotes
resp-1Three-part chest drainOriginal SVGCreated in this rebuild, source code available; clinical schematic review still recommended
resp-2ABG interpretationOriginal SVGCreated in this rebuild, source code available; clinical schematic review still recommended
resp-4Pulmonary embolismOriginal SVGCreated in this rebuild, source code available; clinical schematic review still recommended
resp-5Acute respiratory failureOriginal SVGCreated in this rebuild, source code available; clinical schematic review still recommended
vent-1Oxygen transportOriginal SVGCreated in this rebuild, source code available; clinical schematic review still recommended
vent-3Ventilator physiologyOriginal SVGCreated in this rebuild, source code available; clinical schematic review still recommended
vent-5Determinants of cardiac outputOriginal SVGCreated in this rebuild, source code available; clinical schematic review still recommended
ecg-1Conduction pathwayOriginal SVGCreated in this rebuild, source code available; clinical schematic review still recommended
ecg-2Normal sinus rhythmOriginal SVGCreated in this rebuild, source code available; clinical schematic review still recommended
ecg-2Sinus bradycardiaOriginal SVGCreated in this rebuild, source code available; clinical schematic review still recommended
ecg-2Sinus tachycardiaOriginal SVGCreated in this rebuild, source code available; clinical schematic review still recommended
ecg-2Premature atrial contractionOriginal SVGCreated in this rebuild, source code available; clinical schematic review still recommended
ecg-2Regular supraventricular tachycardiaOriginal SVGCreated in this rebuild, source code available; clinical schematic review still recommended
ecg-2Atrial flutterOriginal SVGCreated in this rebuild, source code available; clinical schematic review still recommended
ecg-2Atrial fibrillationOriginal SVGCreated in this rebuild, source code available; clinical schematic review still recommended
ecg-2Junctional rhythmOriginal SVGCreated in this rebuild, source code available; clinical schematic review still recommended
ecg-3Premature ventricular contractionOriginal SVGCreated in this rebuild, source code available; clinical schematic review still recommended
ecg-3Monomorphic ventricular tachycardiaOriginal SVGCreated in this rebuild, source code available; clinical schematic review still recommended
ecg-3Ventricular fibrillationOriginal SVGCreated in this rebuild, source code available; clinical schematic review still recommended
ecg-3AsystoleOriginal SVGCreated in this rebuild, source code available; clinical schematic review still recommended
ecg-4First-degree atrioventricular blockOriginal SVGCreated in this rebuild, source code available; clinical schematic review still recommended
ecg-4Second-degree AV block, Mobitz IOriginal SVGCreated in this rebuild, source code available; clinical schematic review still recommended
ecg-4Second-degree AV block, Mobitz IIOriginal SVGCreated in this rebuild, source code available; clinical schematic review still recommended
ecg-4Third-degree complete AV blockOriginal SVGCreated in this rebuild, source code available; clinical schematic review still recommended

Medication Mastery — 300 individual profiles

Every entry has a label-search link. The 48 expanded cards are not represented as freshly verified labels; medication dose and route details must be checked against indication-specific and current labeling.

RankDrugClassEditorial statusLabel lookup
1AtorvastatinStatinExpanded study example — unverifiedSearch label
2LevothyroxineThyroid hormoneExpanded study example — unverifiedSearch label
3MetforminBiguanideExpanded study example — unverifiedSearch label
4AmlodipineCalcium-channel blockerExpanded study example — unverifiedSearch label
5LisinoprilACE inhibitorExpanded study example — unverifiedSearch label
6AlbuterolBeta-2 bronchodilatorExpanded study example — unverifiedSearch label
7LosartanARBExpanded study example — unverifiedSearch label
8MetoprololBeta blockerExpanded study example — unverifiedSearch label
9RosuvastatinStatinExpanded study example — unverifiedSearch label
10OmeprazoleProton pump inhibitorExpanded study example — unverifiedSearch label
11GabapentinAnticonvulsantExpanded study example — unverifiedSearch label
12SertralineSSRIExpanded study example — unverifiedSearch label
13EscitalopramSSRIExpanded study example — unverifiedSearch label
14SemaglutideGLP-1 / incretin therapyExpanded study example — unverifiedSearch label
15Mixed amphetamine saltsDrug-specific class—review requiredClass-level overview — unverifiedSearch label
16PantoprazoleProton pump inhibitorExpanded study example — unverifiedSearch label
17BupropionAntidepressant / otherExpanded study example — unverifiedSearch label
18HydrochlorothiazideThiazide diureticExpanded study example — unverifiedSearch label
19FluoxetineSSRIExpanded study example — unverifiedSearch label
20TrazodoneAntidepressant / otherExpanded study example — unverifiedSearch label
21MontelukastOther prescriptionExpanded study example — unverifiedSearch label
22AmoxicillinAntibioticExpanded study example — unverifiedSearch label
23FluticasoneCorticosteroidClass-level overview — unverifiedSearch label
24TamsulosinAlpha-1 antagonistExpanded study example — unverifiedSearch label
25ApixabanAnticoagulantExpanded study example — unverifiedSearch label
26SimvastatinStatinExpanded study example — unverifiedSearch label
27Insulin glargineInsulinExpanded study example — unverifiedSearch label
28EmpagliflozinSGLT2 inhibitorExpanded study example — unverifiedSearch label
29FurosemideLoop diureticExpanded study example — unverifiedSearch label
30MeloxicamNSAIDExpanded study example — unverifiedSearch label
31Hydrocodone/acetaminophenCombination productClass-level overview — unverifiedSearch label
32TirzepatideGLP-1 / incretin therapyExpanded study example — unverifiedSearch label
33MethylphenidateCNS stimulantClass-level overview — unverifiedSearch label
34DuloxetineSNRIExpanded study example — unverifiedSearch label
35PrednisoneCorticosteroidExpanded study example — unverifiedSearch label
36CarvedilolBeta blockerExpanded study example — unverifiedSearch label
37FamotidineGI agentExpanded study example — unverifiedSearch label
38IbuprofenNSAIDExpanded study example — unverifiedSearch label
39BuspironeDrug-specific class—review requiredClass-level overview — unverifiedSearch label
40VenlafaxineSNRIExpanded study example — unverifiedSearch label
41TramadolOpioid analgesicClass-level overview — unverifiedSearch label
42Potassium chlorideElectrolyte replacementExpanded study example — unverifiedSearch label
43HydroxyzineH1 antihistamineClass-level overview — unverifiedSearch label
44AllopurinolOther prescriptionClass-level overview — unverifiedSearch label
45ClopidogrelAntiplateletClass-level overview — unverifiedSearch label
46ErgocalciferolVitamin / mineralClass-level overview — unverifiedSearch label
47CetirizineH1 antihistamineClass-level overview — unverifiedSearch label
48Ondansetron5-HT3 antagonistExpanded study example — unverifiedSearch label
49CyclobenzaprineMuscle relaxantClass-level overview — unverifiedSearch label
50SpironolactonePotassium-sparing diureticExpanded study example — unverifiedSearch label
51OxycodoneOpioid analgesicClass-level overview — unverifiedSearch label
52EstradiolHormonal therapyClass-level overview — unverifiedSearch label
53AspirinNSAIDExpanded study example — unverifiedSearch label
54GlipizideAntidiabetic sulfonylureaClass-level overview — unverifiedSearch label
55ZolpidemDrug-specific class—review requiredClass-level overview — unverifiedSearch label
56LamotrigineAnticonvulsantClass-level overview — unverifiedSearch label
57AlprazolamBenzodiazepineClass-level overview — unverifiedSearch label
58CitalopramSSRIClass-level overview — unverifiedSearch label
59PregabalinAnticonvulsantClass-level overview — unverifiedSearch label
60CholecalciferolVitamin / mineralClass-level overview — unverifiedSearch label
61ClonazepamBenzodiazepineClass-level overview — unverifiedSearch label
62AzithromycinAntibioticClass-level overview — unverifiedSearch label
63PravastatinStatinClass-level overview — unverifiedSearch label
64ValsartanARBClass-level overview — unverifiedSearch label
65EzetimibeOther prescriptionClass-level overview — unverifiedSearch label
66DiclofenacNSAIDClass-level overview — unverifiedSearch label
67Insulin lisproInsulinExpanded study example — unverifiedSearch label
68Ethinyl estradiol/norethindroneHormonal contraceptionClass-level overview — unverifiedSearch label
69PropranololBeta blockerClass-level overview — unverifiedSearch label
70LatanoprostOphthalmic agentClass-level overview — unverifiedSearch label
71AtenololBeta blockerClass-level overview — unverifiedSearch label
72LisdexamfetamineCNS stimulantClass-level overview — unverifiedSearch label
73DoxycyclineAntibioticClass-level overview — unverifiedSearch label
74Amoxicillin/clavulanateCombination productClass-level overview — unverifiedSearch label
75DulaglutideGLP-1 / incretin therapyClass-level overview — unverifiedSearch label
76Lisinopril/hydrochlorothiazideCombination cardiovascular agentClass-level overview — unverifiedSearch label
77LorazepamBenzodiazepineClass-level overview — unverifiedSearch label
78Fluticasone/salmeterolICS + LABAClass-level overview — unverifiedSearch label
79Insulin aspartInsulinExpanded study example — unverifiedSearch label
80CelecoxibNSAIDClass-level overview — unverifiedSearch label
81FinasterideOther prescriptionClass-level overview — unverifiedSearch label
82QuetiapineAntipsychoticClass-level overview — unverifiedSearch label
83ClonidineOther cardiovascularClass-level overview — unverifiedSearch label
84AripiprazoleAntipsychoticClass-level overview — unverifiedSearch label
85CephalexinAntibioticClass-level overview — unverifiedSearch label
86AlendronateDrug-specific class—review requiredClass-level overview — unverifiedSearch label
87TopiramateAnticonvulsantClass-level overview — unverifiedSearch label
88TizanidineMuscle relaxantClass-level overview — unverifiedSearch label
89DapagliflozinSGLT2 inhibitorClass-level overview — unverifiedSearch label
90Oxycodone/acetaminophenCombination productClass-level overview — unverifiedSearch label
91Losartan/hydrochlorothiazideCombination cardiovascular agentClass-level overview — unverifiedSearch label
92OlmesartanARBClass-level overview — unverifiedSearch label
93TestosteroneHormonal therapyClass-level overview — unverifiedSearch label
94AmitriptylineAntidepressant / otherClass-level overview — unverifiedSearch label
95Folic acidVitamin / mineralClass-level overview — unverifiedSearch label
96RivaroxabanAnticoagulantClass-level overview — unverifiedSearch label
97FenofibrateOther prescriptionClass-level overview — unverifiedSearch label
98TriamcinoloneCorticosteroidClass-level overview — unverifiedSearch label
99ParoxetineSSRIClass-level overview — unverifiedSearch label
100Ferrous sulfateVitamin / mineralClass-level overview — unverifiedSearch label
101LoratadineH1 antihistamineClass-level overview — unverifiedSearch label
102WarfarinAnticoagulantExpanded study example — unverifiedSearch label
103ValacyclovirAntiviralClass-level overview — unverifiedSearch label
104Budesonide/formoterolICS + LABAClass-level overview — unverifiedSearch label
105Ethinyl estradiol/norgestimateHormonal contraceptionClass-level overview — unverifiedSearch label
106Fluticasone/umeclidinium/vilanterolICS + LAMA + LABAClass-level overview — unverifiedSearch label
107MethocarbamolMuscle relaxantClass-level overview — unverifiedSearch label
108AcetaminophenAnalgesic / antipyreticExpanded study example — unverifiedSearch label
109DiltiazemCalcium-channel blockerClass-level overview — unverifiedSearch label
110Desiccated thyroidDrug-specific class—review requiredClass-level overview — unverifiedSearch label
111BaclofenMuscle relaxantClass-level overview — unverifiedSearch label
112NaproxenNSAIDClass-level overview — unverifiedSearch label
113SumatriptanMigraine medicationClass-level overview — unverifiedSearch label
114PrednisoloneCorticosteroidClass-level overview — unverifiedSearch label
115EsomeprazoleProton pump inhibitorClass-level overview — unverifiedSearch label
116MirtazapineAntidepressant / otherClass-level overview — unverifiedSearch label
117LevetiracetamAnticonvulsantClass-level overview — unverifiedSearch label
118NorethindroneHormonal therapyClass-level overview — unverifiedSearch label
119TadalafilPDE5 inhibitorClass-level overview — unverifiedSearch label
120NifedipineCalcium-channel blockerClass-level overview — unverifiedSearch label
121ProgesteroneHormonal therapyClass-level overview — unverifiedSearch label
122Insulin degludecInsulinClass-level overview — unverifiedSearch label
123CyanocobalaminVitamin / mineralClass-level overview — unverifiedSearch label
124HydralazineOther cardiovascularClass-level overview — unverifiedSearch label
125AdalimumabImmunomodulatorClass-level overview — unverifiedSearch label
126AzelastineH1 antihistamineClass-level overview — unverifiedSearch label
127SitagliptinAntidiabetic DPP-4 inhibitorClass-level overview — unverifiedSearch label
128GlimepirideAntidiabetic sulfonylureaClass-level overview — unverifiedSearch label
129ChlorthalidoneThiazide diureticClass-level overview — unverifiedSearch label
130OxybutyninDrug-specific class—review requiredClass-level overview — unverifiedSearch label
131PioglitazoneAntidiabetic TZDClass-level overview — unverifiedSearch label
132KetoconazoleAntifungalClass-level overview — unverifiedSearch label
133IrbesartanARBClass-level overview — unverifiedSearch label
134HydroxychloroquineImmunomodulatorClass-level overview — unverifiedSearch label
135Sulfamethoxazole/trimethoprimCombination productClass-level overview — unverifiedSearch label
136BenzonatateOther prescriptionClass-level overview — unverifiedSearch label
137NitrofurantoinAntibioticClass-level overview — unverifiedSearch label
138Isosorbide mononitrateOther cardiovascularClass-level overview — unverifiedSearch label
139MethylprednisoloneCorticosteroidClass-level overview — unverifiedSearch label
140Triamterene/hydrochlorothiazideCombination cardiovascular agentClass-level overview — unverifiedSearch label
141LevocetirizineH1 antihistamineClass-level overview — unverifiedSearch label
142ClindamycinAntibioticClass-level overview — unverifiedSearch label
143AtomoxetineDrug-specific class—review requiredClass-level overview — unverifiedSearch label
144DexmethylphenidateCNS stimulantClass-level overview — unverifiedSearch label
145MethotrexateAntimetabolite / DMARDExpanded study example — unverifiedSearch label
146DonepezilOther neurologicClass-level overview — unverifiedSearch label
147DesvenlafaxineSNRIClass-level overview — unverifiedSearch label
148RopiniroleOther neurologicClass-level overview — unverifiedSearch label
149ClobetasolCorticosteroidClass-level overview — unverifiedSearch label
150Fluticasone/vilanterolICS + LABAClass-level overview — unverifiedSearch label
151Albuterol/ipratropiumSABA + SAMAClass-level overview — unverifiedSearch label
152PhentermineCNS stimulantClass-level overview — unverifiedSearch label
153OfloxacinAntibioticClass-level overview — unverifiedSearch label
154MupirocinAntibioticClass-level overview — unverifiedSearch label
155VerapamilCalcium-channel blockerClass-level overview — unverifiedSearch label
156OlanzapineAntipsychoticClass-level overview — unverifiedSearch label
157MetronidazoleAntibioticClass-level overview — unverifiedSearch label
158PrazosinAlpha-1 antagonistClass-level overview — unverifiedSearch label
159CiprofloxacinAntibioticClass-level overview — unverifiedSearch label
160SildenafilPDE5 inhibitorClass-level overview — unverifiedSearch label
161Ethinyl estradiol/levonorgestrelHormonal contraceptionClass-level overview — unverifiedSearch label
162EvolocumabDrug-specific class—review requiredClass-level overview — unverifiedSearch label
163MesalamineGI agentClass-level overview — unverifiedSearch label
164MemantineOther neurologicClass-level overview — unverifiedSearch label
165Ethinyl estradiol/etonogestrelHormonal contraceptionClass-level overview — unverifiedSearch label
166DiazepamBenzodiazepineClass-level overview — unverifiedSearch label
167LithiumMood stabilizerClass-level overview — unverifiedSearch label
168NortriptylineAntidepressant / otherClass-level overview — unverifiedSearch label
169TimololBeta blockerClass-level overview — unverifiedSearch label
170CefdinirAntibioticClass-level overview — unverifiedSearch label
171Magnesium saltsDrug-specific class—review requiredClass-level overview — unverifiedSearch label
172MeclizineH1 antihistamineClass-level overview — unverifiedSearch label
173CyclosporineImmunomodulatorClass-level overview — unverifiedSearch label
174FluconazoleAntifungalClass-level overview — unverifiedSearch label
175RimegepantMigraine medicationClass-level overview — unverifiedSearch label
176TretinoinDermatologicClass-level overview — unverifiedSearch label
177LovastatinStatinClass-level overview — unverifiedSearch label
178Drospirenone/ethinyl estradiolHormonal contraceptionClass-level overview — unverifiedSearch label
179TiotropiumAnticholinergic bronchodilatorClass-level overview — unverifiedSearch label
180DocusateGI agentClass-level overview — unverifiedSearch label
181TemazepamBenzodiazepineClass-level overview — unverifiedSearch label
182BenazeprilACE inhibitorClass-level overview — unverifiedSearch label
183BrimonidineOphthalmic agentClass-level overview — unverifiedSearch label
184Sacubitril/valsartanCombination cardiovascular agentClass-level overview — unverifiedSearch label
185ValproateAnticonvulsantClass-level overview — unverifiedSearch label
186NebivololBeta blockerClass-level overview — unverifiedSearch label
187AcyclovirAntiviralClass-level overview — unverifiedSearch label
188MorphineOpioid analgesicClass-level overview — unverifiedSearch label
189DoxazosinAlpha-1 antagonistClass-level overview — unverifiedSearch label
190Amlodipine/benazeprilCombination cardiovascular agentClass-level overview — unverifiedSearch label
191Nirmatrelvir/ritonavirCombination productClass-level overview — unverifiedSearch label
192Emtricitabine/tenofovirCombination productClass-level overview — unverifiedSearch label
193BudesonideCorticosteroidClass-level overview — unverifiedSearch label
194TacrolimusImmunomodulatorClass-level overview — unverifiedSearch label
195DupilumabImmunomodulatorClass-level overview — unverifiedSearch label
196EnalaprilACE inhibitorClass-level overview — unverifiedSearch label
197AnastrozoleDrug-specific class—review requiredClass-level overview — unverifiedSearch label
198MelatoninDrug-specific class—review requiredClass-level overview — unverifiedSearch label
199TorsemideLoop diureticClass-level overview — unverifiedSearch label
200Polyethylene glycol 3350Drug-specific class—review requiredClass-level overview — unverifiedSearch label
201NitroglycerinNitrate vasodilatorExpanded study example — unverifiedSearch label
202KetorolacNSAIDClass-level overview — unverifiedSearch label
203FlecainideOther cardiovascularClass-level overview — unverifiedSearch label
204LiothyronineDrug-specific class—review requiredClass-level overview — unverifiedSearch label
205TelmisartanARBClass-level overview — unverifiedSearch label
206RisperidoneAntipsychoticClass-level overview — unverifiedSearch label
207ColchicineOther prescriptionClass-level overview — unverifiedSearch label
208LansoprazoleProton pump inhibitorClass-level overview — unverifiedSearch label
209Regular/NPH insulin mixtureInsulinClass-level overview — unverifiedSearch label
210OxcarbazepineAnticonvulsantClass-level overview — unverifiedSearch label
211PromethazineDrug-specific class—review requiredClass-level overview — unverifiedSearch label
212DicyclomineGI agentClass-level overview — unverifiedSearch label
213CalciumVitamin / mineralClass-level overview — unverifiedSearch label
214MinoxidilOther cardiovascularClass-level overview — unverifiedSearch label
215LinaclotideGI agentClass-level overview — unverifiedSearch label
216MetoclopramideGI agentClass-level overview — unverifiedSearch label
217RizatriptanMigraine medicationClass-level overview — unverifiedSearch label
218OseltamivirAntiviralClass-level overview — unverifiedSearch label
219NystatinAntifungalClass-level overview — unverifiedSearch label
220Dorzolamide/timololCombination productClass-level overview — unverifiedSearch label
221Budesonide/glycopyrrolate/formoterolICS + LAMA + LABAClass-level overview — unverifiedSearch label
222TerazosinAlpha-1 antagonistClass-level overview — unverifiedSearch label
223DexlansoprazoleProton pump inhibitorClass-level overview — unverifiedSearch label
224Acetaminophen/codeineCombination productClass-level overview — unverifiedSearch label
225ErythromycinAntibioticClass-level overview — unverifiedSearch label
226DorzolamideOphthalmic agentClass-level overview — unverifiedSearch label
227HydrocortisoneCorticosteroidClass-level overview — unverifiedSearch label
228BisoprololBeta blockerClass-level overview — unverifiedSearch label
229SolifenacinDrug-specific class—review requiredClass-level overview — unverifiedSearch label
230CarbamazepineAnticonvulsantClass-level overview — unverifiedSearch label
231Betamethasone/clotrimazoleCombination productClass-level overview — unverifiedSearch label
232DextroamphetamineCNS stimulantClass-level overview — unverifiedSearch label
233Omega-3-acid ethyl estersDrug-specific class—review requiredClass-level overview — unverifiedSearch label
234EpinephrineNonselective adrenergic agonistExpanded study example — unverifiedSearch label
235LevofloxacinAntibioticClass-level overview — unverifiedSearch label
236Promethazine/dextromethorphanCombination productClass-level overview — unverifiedSearch label
237RamiprilACE inhibitorClass-level overview — unverifiedSearch label
238LoperamideGI agentClass-level overview — unverifiedSearch label
239MirabegronDrug-specific class—review requiredClass-level overview — unverifiedSearch label
240MedroxyprogesteroneHormonal therapyClass-level overview — unverifiedSearch label
241DexamethasoneCorticosteroidClass-level overview — unverifiedSearch label
242SucralfateGI agentClass-level overview — unverifiedSearch label
243UbrogepantMigraine medicationClass-level overview — unverifiedSearch label
244PramipexoleOther neurologicClass-level overview — unverifiedSearch label
245CalcitriolVitamin / mineralClass-level overview — unverifiedSearch label
246IpratropiumAnticholinergic bronchodilatorClass-level overview — unverifiedSearch label
247TicagrelorAntiplateletClass-level overview — unverifiedSearch label
248FexofenadineH1 antihistamineClass-level overview — unverifiedSearch label
249PancrelipaseOther prescriptionClass-level overview — unverifiedSearch label
250Polymyxin B/trimethoprimCombination productClass-level overview — unverifiedSearch label
251BumetanideLoop diureticClass-level overview — unverifiedSearch label
252LabetalolBeta blockerClass-level overview — unverifiedSearch label
253Sodium saltsDrug-specific class—review requiredClass-level overview — unverifiedSearch label
254AlfuzosinAlpha-1 antagonistClass-level overview — unverifiedSearch label
255Senna/docusateCombination productClass-level overview — unverifiedSearch label
256MoxifloxacinAntibioticClass-level overview — unverifiedSearch label
257ClotrimazoleAntifungalClass-level overview — unverifiedSearch label
258TerbinafineAntifungalClass-level overview — unverifiedSearch label
259IsotretinoinDermatologicClass-level overview — unverifiedSearch label
260NPH insulinInsulinClass-level overview — unverifiedSearch label
261Calcium phosphate/cholecalciferolCombination productClass-level overview — unverifiedSearch label
262Insulin detemirInsulinClass-level overview — unverifiedSearch label
263LetrozoleDrug-specific class—review requiredClass-level overview — unverifiedSearch label
264Sodium fluorideDrug-specific class—review requiredClass-level overview — unverifiedSearch label
265Acetaminophen/butalbital/caffeineCombination productClass-level overview — unverifiedSearch label
266CiclopiroxAntifungalClass-level overview — unverifiedSearch label
267CyproheptadineH1 antihistamineClass-level overview — unverifiedSearch label
268AmiodaroneClass III antiarrhythmicExpanded study example — unverifiedSearch label
269Ethinyl estradiol/norelgestrominHormonal contraceptionClass-level overview — unverifiedSearch label
270Desogestrel/ethinyl estradiolHormonal contraceptionClass-level overview — unverifiedSearch label
271ChlorhexidineDrug-specific class—review requiredClass-level overview — unverifiedSearch label
272NabumetoneNSAIDClass-level overview — unverifiedSearch label
273LidocaineLocal anesthetic / class Ib antiarrhythmicExpanded study example — unverifiedSearch label
274HydroquinoneDermatologicClass-level overview — unverifiedSearch label
275Codeine/guaifenesinCombination productClass-level overview — unverifiedSearch label
276Dexamethasone/neomycin/polymyxin BCombination productClass-level overview — unverifiedSearch label
277PEG-electrolyte bowel preparationDrug-specific class—review requiredClass-level overview — unverifiedSearch label
278Penicillin VDrug-specific class—review requiredClass-level overview — unverifiedSearch label
279DiphenhydramineH1 antihistamineClass-level overview — unverifiedSearch label
280LevalbuterolBeta-2 bronchodilatorClass-level overview — unverifiedSearch label
281Lactate saltsDrug-specific class—review requiredClass-level overview — unverifiedSearch label
282LiraglutideGLP-1 / incretin therapyClass-level overview — unverifiedSearch label
283GuanfacineDrug-specific class—review requiredClass-level overview — unverifiedSearch label
284BetamethasoneCorticosteroidClass-level overview — unverifiedSearch label
285MometasoneCorticosteroidClass-level overview — unverifiedSearch label
286FluorouracilDermatologicClass-level overview — unverifiedSearch label
287BeclomethasoneCorticosteroidClass-level overview — unverifiedSearch label
288Loratadine/pseudoephedrineCombination productClass-level overview — unverifiedSearch label
289Ascorbic acidVitamin / mineralClass-level overview — unverifiedSearch label
290Mycophenolate mofetilImmunomodulatorClass-level overview — unverifiedSearch label
291OlopatadineH1 antihistamineClass-level overview — unverifiedSearch label
292IndomethacinNSAIDClass-level overview — unverifiedSearch label
293Brompheniramine/dextromethorphan/pseudoephedrineCombination productClass-level overview — unverifiedSearch label
294Benzoyl peroxideDrug-specific class—review requiredClass-level overview — unverifiedSearch label
295Ciprofloxacin/dexamethasoneCombination productClass-level overview — unverifiedSearch label
296PhenazopyridineDrug-specific class—review requiredClass-level overview — unverifiedSearch label
297CefuroximeAntibioticClass-level overview — unverifiedSearch label
298ThiamineVitamin / mineralClass-level overview — unverifiedSearch label
299Ethinyl estradiol/norgestrelHormonal contraceptionClass-level overview — unverifiedSearch label
300Sulfacetamide/sulfurCombination productClass-level overview — unverifiedSearch label

Interaction practice — 22 paired rules

Rule existence does not establish an exhaustive clinical interaction checker. Empty or unknown results must not be interpreted as evidence of safety.

IDPairApp severityApp rationaleLabel status
INTERACTION-001Warfarin + IbuprofenMajorIncreased bleeding risk with warfarin and an NSAID. Avoid unsupervised combination; check INR/bleeding and prescriber plan.FDA label reconciliation pending
INTERACTION-002Warfarin + NaproxenMajorWarfarin plus NSAID increases bleeding risk; discuss alternative analgesia and monitor.FDA label reconciliation pending
INTERACTION-003Warfarin + AspirinMajorAdditive antithrombotic effect increases bleeding; combinations require a specific indication and monitoring.FDA label reconciliation pending
INTERACTION-004Apixaban + IbuprofenMajorDOAC plus NSAID increases GI and other bleeding risk.FDA label reconciliation pending
INTERACTION-005Apixaban + AspirinMajorAdditive bleeding risk; dual therapy requires a documented indication.FDA label reconciliation pending
INTERACTION-006Rivaroxaban + IbuprofenMajorDOAC plus NSAID increases bleeding risk.FDA label reconciliation pending
INTERACTION-007Rivaroxaban + AspirinMajorAdditive bleeding risk; verify reason for combination.FDA label reconciliation pending
INTERACTION-008Clopidogrel + OmeprazoleSignificantOmeprazole inhibits CYP2C19 and may reduce clopidogrel activation; label guidance favors avoiding this combination.FDA label reconciliation pending
INTERACTION-009Clopidogrel + EsomeprazoleSignificantEsomeprazole inhibits CYP2C19 and may reduce clopidogrel antiplatelet activation.FDA label reconciliation pending
INTERACTION-010Lisinopril + SpironolactoneSignificantACE inhibitor plus potassium-sparing diuretic can cause hyperkalemia; monitor potassium and kidney function.FDA label reconciliation pending
INTERACTION-011Losartan + SpironolactoneSignificantARB plus potassium-sparing diuretic increases hyperkalemia risk.FDA label reconciliation pending
INTERACTION-012Lisinopril + LosartanAvoid combinationDual renin-angiotensin blockade raises renal injury, hypotension and hyperkalemia risk with limited benefit.FDA label reconciliation pending
INTERACTION-013Sildenafil + NitroglycerinContraindicatedPDE5 inhibitor plus nitrate can cause severe hypotension. Never coadminister; check timing and local emergency protocols.FDA label reconciliation pending
INTERACTION-014Tadalafil + NitroglycerinContraindicatedPDE5 inhibitor plus nitrate can cause profound hypotension; tadalafil has a prolonged effect.FDA label reconciliation pending
INTERACTION-015Oxycodone + AlprazolamMajorOpioid plus benzodiazepine: additive sedation and respiratory depression.FDA label reconciliation pending
INTERACTION-016Morphine + LorazepamMajorOpioid plus benzodiazepine increases sedation and respiratory-depression risk.FDA label reconciliation pending
INTERACTION-017Tramadol + SertralineSignificantSerotonergic activity raises serotonin-syndrome and seizure concerns.FDA label reconciliation pending
INTERACTION-018Tramadol + FluoxetineSignificantSerotonin syndrome/seizure risk; fluoxetine CYP2D6 effects may change tramadol metabolism.FDA label reconciliation pending
INTERACTION-019Metoprolol + VerapamilSignificantCombined AV-nodal suppression can produce severe bradycardia, AV block or hypotension.FDA label reconciliation pending
INTERACTION-020Metoprolol + DiltiazemSignificantCombined AV-nodal blockade increases bradycardia and hypotension risk.FDA label reconciliation pending
INTERACTION-021Lithium + IbuprofenSignificantNSAIDs may decrease lithium renal clearance, increasing toxicity risk.FDA label reconciliation pending
INTERACTION-022Lithium + HydrochlorothiazideSignificantThiazides can raise lithium concentrations and toxicity risk.FDA label reconciliation pending

Source reuse permissions

ReferencePermissionsPermitted workflow
Open RN Health Alterations (2024)CC BY 4.0, check embedded third-party itemsReusable text subject to specific embedded exclusions, with credit
Open RN Health Alterations: Respiratory AlterationsCC BY 4.0; embedded NC exceptionsEducational framework; avoid reuse of separately credited NC items
Open RN Nursing Skills 2eCC BY 4.0, check embedded rightsClinical skills and safety background
Open RN Nursing Pharmacology 2eCC BY 4.0, check embedded rightsDrug class background; not dose formulary
Open RN OER textbook collection (Advanced Skills available)CC BY 4.0 at collection level; embedded rights may differOpen nursing skills and critical-care fundamentals
MedlinePlus: Public domain vs third-party content policyPublic domain only for listed original US federal sectionsFacts/reference; exclude A.D.A.M., ASHP drug monographs and uncredited images
AHA 2025 Adult Advanced Life Support GuidelineCopyrighted reference; link/cite onlyResuscitation and rhythm decisions; no copyrighted artwork or passages reproduced
2026 AHA/ACC multi-society acute pulmonary embolism guidelineCopyrighted reference; link/cite onlyDiagnostic/treatment reference; original authoring required
2024 AARC spontaneous breathing trial clinical practice guidelinePublicly readable; reuse rights need separate checkReference findings; do not lift wording, graphics or tables
ATS/ESICM/SCCM mechanical ventilation guidelineCopyrighted reference; link/cite onlyLung-protective ventilation concepts
ACOG 2025 Intrapartum FHR Monitoring, CPG 10Copyrighted and partly member-onlyReference only; no charts/tables/algorithms copied
DailyMed: NIH/NLM label accessLabel-by-label rights not blanket CC grantFDA-submitted drug labeling reference; verify per medication
Creative Commons Attribution 4.0License instrumentAttribution/license/changes must accompany adapted content

Remaining clinical and legal verification

Requires a qualified clinical editor to confirm each learning item's answer/explanation and the labeling of each medication and interaction, particularly where current dosing, contraindications, resuscitation algorithms or diagnostic decisions appear. Verify the original authorship of remaining inherited lesson text, terms and ranking data before representing the full site as cleared for commercial reuse. This is an editorial traceability register, not legal advice.

Report produced October 26, 2026. See AUDIT_INDEX_ITEM_BY_ITEM.json and AUDIT_MEDICATIONS_INTERACTIONS.json in the private archive for machine-readable records.

Clinical & Provenance Review Register (2026) · Item-level evidence and limits